Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles (Q34279396)

1 August 2017

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles (English)

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1 August 2017

5

Li-Huei Tsai

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1 August 2017

Jonathan C Cruz

1

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1 August 2017

Huang-Chun Tseng

series ordinal

2

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1 August 2017

Joseph A Goldman

series ordinal

3

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1 August 2017

Heather Shih

series ordinal

4

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1 August 2017

language of work or name

English

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publication date

1 October 2003

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1 August 2017

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1 August 2017

40

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1 August 2017

471-483

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1 August 2017

3

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Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

1 August 2017

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https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

A Cdk5-p35 stable complex is involved in the beta-amyloid-induced deregulation of Cdk5 activity in hippocampal neurons

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https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Improved reversal learning and altered fear conditioning in transgenic mice with regionally restricted p25 expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

A clinical pathological comparison of three families with frontotemporal dementia and identical mutations in the tau gene (P301L)

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann-Pick type C murine model.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Temporal and spatial patterns of expression of p35, a regulatory subunit of cyclin-dependent kinase 5, in the nervous system of the mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

1 reference

7 January 2021

Aberrant activation of focal adhesion proteins mediates fibrillar amyloid beta-induced neuronal dystrophy.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Life is a journey: a genetic look at neocortical development

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https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Porcine brain neurofilament-H tail domain kinase: its identification as cdk5/p26 complex and comparison with cdc2/cyclin B kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

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https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling

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https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment

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https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25

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https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

A brain-specific activator of cyclin-dependent kinase 5.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Stabilization of the cyclin-dependent kinase 5 activator, p35, by paclitaxel decreases beta-amyloid toxicity in cortical neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Control of memory formation through regulated expression of a CaMKII transgene

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Processing of cdk5 Activator p35 to Its Truncated Form (p25) by Calpain in Acutely Injured Neuronal Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Cdk5 is a key factor in tau aggregation and tangle formation in vivo.

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https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576.

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https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Comparative analysis of an improved thioflavin-s stain, Gallyas silver stain, and immunohistochemistry for neurofibrillary tangle demonstration on the same sections.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Involvement of cyclin dependent kinase5 activator p25 on tau phosphorylation in mouse brain

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Localization and developmental changes in the neuron-specific cyclin-dependent kinase 5 activator (p35nck5a) in the rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Coexpression of human cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: involvement of Src family protein kinases.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

A neuronal antigen in the brains of Alzheimer patients

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Neurobiology: p25 protein in neurodegeneration

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https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

Cdk5 phosphorylates p53 and regulates its activity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

The role of mitogen-activated protein kinase pathways in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900627-5

7 January 2021

10.1016/S0896-6273(03)00627-5

Identifiers

DOI

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1 August 2017

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