Adeno-associated Viral (AAV) Serotype 5 Vector Mediated Gene Delivery of Endothelin-converting Enzyme Reduces Aβ Deposits in APP + PS1 Transgenic Mice (Q64360450)

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English	Adeno-associated Viral (AAV) Serotype 5 Vector Mediated Gene Delivery of Endothelin-converting Enzyme Reduces Aβ Deposits in APP + PS1 Transgenic Mice	article

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scholarly article

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Adeno-associated Viral (AAV) Serotype 5 Vector Mediated Gene Delivery of Endothelin-converting Enzyme Reduces Aβ Deposits in APP + PS1 Transgenic Mice (English)

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author name string

Niki C Carty

1

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Kevin Nash

2

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Daniel Lee

3

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Mary Mercer

4

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Paul E Gottschall

5

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Craig Meyers

6

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Nicholas Muzyczka

7

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Marcia N Gordon

8

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Dave Morgan

9

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language of work or name

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publication date

September 2008

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Molecular Therapy

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16

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9

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1580-1586

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Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide.

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Rat endothelin-converting enzyme-1 forms a dimer through Cys412 with a similar catalytic mechanism and a distinct substrate binding mechanism compared with neutral endopeptidase-24.11

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10.1038/MT.2008.148

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