The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase (Q64388322)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16936775%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

title

The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16936775%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16936775%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

author name string

M Oliva-Trastoy

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16936775%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

V Berthonaud

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16936775%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

A Chevalier

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16936775%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

C Ducrot

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16936775%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

M-C Marsolier-Kergoat

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16936775%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

F Leteurtre

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16936775%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

language of work or name

English

0 references

publication date

28 August 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16936775%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16936775%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

volume

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16936775%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

page(s)

1449-1458

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16936775%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16936775%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/sj.onc.1209927

29 December 2019

exact match

0 references

cites work

Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

The Chk2 protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Chk1 and Chk2 kinases in checkpoint control and cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

The regulation of CHK2 in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Chk2 molecular interaction map and rationale for Chk2 inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Plant PP2C phosphatases: emerging functions in stress signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

The 17q23 amplicon and breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Characterization of tumor-associated Chk2 mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Chk2 activation and phosphorylation-dependent oligomerization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Substrate specificity of the human protein phosphatase 2Cdelta, Wip1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021

The DNA damage response: putting checkpoints in perspective

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209927

7 January 2021