Lymphocyte cytosolic protein 2 (Q6708256)

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mammalian protein found in Homo sapiens
  • SLP-76 tyrosine phosphoprotein
  • SH2 domain-containing leukocyte protein of 76 kDa
  • SLP76
  • 76 kDa tyrosine phosphoprotein
  • LCP2
  • lymphocyte cytosolic protein 2
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Language Label Description Also known as
English
Lymphocyte cytosolic protein 2
mammalian protein found in Homo sapiens
  • SLP-76 tyrosine phosphoprotein
  • SH2 domain-containing leukocyte protein of 76 kDa
  • SLP76
  • 76 kDa tyrosine phosphoprotein
  • LCP2
  • lymphocyte cytosolic protein 2

Statements

molecular function
protein binding
determination method
IPI
30 references
retrieved
8 April 2019
stated in
ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion
GOA
curator
UniProt
UniProt protein ID
Q13094
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Cooperative interactions at the SLP-76 complex are critical for actin polymerization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Functional association between SLAP-130 and SLP-76 in Jurkat T cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Cutting edge: SLP-76 cooperativity with FYB/FYN-T in the Up-regulation of TCR-driven IL-2 transcription requires SLP-76 binding to FYB at Tyr595 and Tyr651
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Phospho-tyrosine dependent protein-protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Expression, refolding and crystallizations of the Grb2-like (GADS) C-terminal SH3 domain complexed with a SLP-76 motif peptide
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Charting the molecular network of the drug target Bcr-Abl
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Improved two-dimensional reversed phase-reversed phase LC-MS/MS approach for identification of peptide-protein interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of the C-terminal SH3 domain of the adaptor protein GADS in complex with SLP-76 motif peptide reveals a unique SH3-SH3 interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Novel Src homology 3 domain-binding motifs identified from proteomic screen of a Pro-rich region
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
retrieved
8 April 2019
stated in
Pooled-matrix protein interaction screens using Barcode Fusion Genetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13094
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE LCP2 205269 at fs.png
732 × 530; 11 KB
0 references

Identifiers

 
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