Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2 (Q24337925)

GRB2-related adaptor protein 2

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Louise E Bird

6

0 references

Nicola O'Reilly

object named as

Nicola O'Reilly

8

0 references

Yvonne Jones

7

object named as

E Yvonne Jones

0 references

author name string

Maria Harkiolaki

1

0 references

Theodora Tsirka

2

0 references

Marc Lewitzky

3

0 references

Philip C Simister

4

0 references

Dhira Joshi

5

0 references

Stephan M Feller

Grb2-SH3 ligand inhibits the growth of HER2+ cancer cells and has antitumor effects in human cancer xenografts alone and in combination with docetaxel

9

0 references

language of work or name

English

0 references

publication date

10 June 2009

0 references

published in

Structure

0 references

volume

17

0 references

page(s)

809-22

0 references

issue

6

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

The tyrosine phosphatase HD-PTP: A novel player in endothelial migration

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

In silico screening and biological evaluation of inhibitors of Src-SH3 domain interaction with a proline-rich ligand

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

MDM2 inhibitors for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

p130Cas: a versatile scaffold in signaling networks

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Tissue-specific roles of IRS proteins in insulin signaling and glucose transport

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

1 reference

7 January 2021

SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

The "Gab" in signal transduction.

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

How to make tubes: signaling by the Met receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Integrin signalling: a new Cas(t) of characters enters the stage

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Critical role for Gab2 in transformation by BCR/ABL

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Protein-protein interactions as targets for small-molecule therapeutics in cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Essential role for Gab2 in the allergic response

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Stops along the RAS pathway in human genetic disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

A role for the scaffolding adapter GAB2 in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Grb2 downregulation leads to Akt inactivation in heregulin-stimulated and ErbB2-overexpressing breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Biologic and therapeutic role of HER2 in cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Role of Gab2 in mammary tumorigenesis and metastasis.

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Engagement of Gab1 and Gab2 in erythropoietin signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27.

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Mona/Gads SH3C binding to hematopoietic progenitor kinase 1 (HPK1) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Essential role of Gab1 for signaling by the c-Met receptor in vivo

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells.

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

A versatile ligation-independent cloning method suitable for high-throughput expression screening applications

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Defects of the insulin receptor substrate (IRS) system in human metabolic disorders

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Inhibition of tumor metastasis by a growth factor receptor bound protein 2 Src homology 2 domain-binding antagonist.

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Genetic screening reveals an essential role of p27kip1 in restriction of breast cancer progression

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4.

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Abnormal hematopoiesis in Gab2 mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Requirement of Gab2 for mast cell development and KitL/c-Kit signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021

Potential disease targets for drugs that disrupt protein-- protein interactions of Grb2 and Crk family adaptors

1 reference

https://api.crossref.org/works/10.1016%2FJ.STR.2009.03.017

7 January 2021