High-Throughput Screening Identifies Mixed-Lineage Kinase 3 as a Key Host Regulatory Factor in Zika Virus Infection (Q67087239)

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23 April 2020

title

High-Throughput Screening Identifies Mixed-Lineage Kinase 3 as a Key Host Regulatory Factor in Zika Virus Infection (English)

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23 April 2020

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Mitogen-activated protein kinase kinase kinase 11

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author name string

Hua Xu

1

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23 April 2020

Min Cheng

2

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23 April 2020

Xiaojing Chi

3

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23 April 2020

Xiuying Liu

4

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23 April 2020

Jia Zhou

5

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23 April 2020

Tianli Lin

6

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23 April 2020

Wei Yang

7

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23 April 2020

publication date

28 August 2019

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23 April 2020

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23 April 2020

volume

93

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23 April 2020

issue

18

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Expression of the Potent Inflammatory Cytokines, GM-CSF, IL6, and IL8, in Bronchial Epithelial Cells of Asthmatic Patients

23 April 2020

cites work

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12 December 2020

MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain

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The JNK/SAPK activator mixed lineage kinase 3 (MLK3) transforms NIH 3T3 cells in a MEK-dependent fashion

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Sendai virus blocks alpha interferon signaling to signal transducers and activators of transcription

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Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex

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Analysis of the gene expression profile activated by the CC chemokine ligand 5/RANTES and by lipopolysaccharide in human monocytes

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12 December 2020

Zika virus. I. Isolations and serological specificity

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12 December 2020

Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination.

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12 December 2020

Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells

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12 December 2020

Expression profiles of cytokines in the brains of Alzheimer's disease (AD) patients compared to the brains of non-demented patients with and without increasing AD pathology

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12 December 2020

TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway

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12 December 2020

HBx activates FasL and mediates HepG2 cell apoptosis through MLK3-MKK7-JNKs signal module

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12 December 2020

Enterovirus 71 protease 2Apro targets MAVS to inhibit anti-viral type I interferon responses

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12 December 2020

Differential gene expressions of the MAPK signaling pathway in enterovirus 71-infected rhabdomyosarcoma cells

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12 December 2020

Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.

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12 December 2020

In vitro screen of a small molecule inhibitor drug library identifies multiple compounds that synergize with oncolytic myxoma virus against human brain tumor-initiating cells

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12 December 2020

Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes

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12 December 2020

Zika Virus Associated with Microcephaly

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12 December 2020

Zika Virus as a Cause of Neurologic Disorders

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12 December 2020

Isolation, identification and genomic characterization of the Asian lineage Zika virus imported to China

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Zika Virus and Birth Defects — Reviewing the Evidence for Causality

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AP1S3 is required for hepatitis C virus infection by stabilizing E2 protein

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12 December 2020

Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice

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12 December 2020

A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection

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12 December 2020

Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy

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12 December 2020

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

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12 December 2020

Zika antiviral chemotherapy: identification of drugs and promising starting points for drug discovery from an FDA-approved library

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12 December 2020

Zika virus cell tropism in the developing human brain and inhibition by azithromycin

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12 December 2020

Evaluation of anti-Zika virus activities of broad-spectrum antivirals and NIH clinical collection compounds using a cell-based, high-throughput screen assay

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12 December 2020

Immune activation in amniotic fluid from Zika virus-associated microcephaly

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12 December 2020

Purification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitors

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12 December 2020

Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus

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12 December 2020

Zika Virus Antagonizes Type I Interferon Responses during Infection of Human Dendritic Cells

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12 December 2020

Induction of intestinal stemness and tumorigenicity by aberrant internalization of commensal non-pathogenic E. coli

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12 December 2020

Selective Activation of Type II Interferon Signaling by Zika Virus NS5 Protein

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12 December 2020

Zika virus evolution and spread in the Americas

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12 December 2020

Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction

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12 December 2020

High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain.

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12 December 2020

Identification of novel small-molecule inhibitors of Zika virus infection

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12 December 2020

Development of a replicon cell line-based high throughput antiviral assay for screening inhibitors of Zika virus

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12 December 2020

Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease

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12 December 2020

Preparation of Respiratory Syncytial Virus with High or Low Content of Defective Viral Particles and Their Purification from Viral Stocks

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12 December 2020

Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques

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12 December 2020

An orthogonal proteomic survey uncovers novel Zika virus host factors

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12 December 2020

Identifiers

DOI

10.1128/JVI.00758-19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31270223%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

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23 April 2020

PubMed publication ID

31270223

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