TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway (Q24634905)

6

object named as

Richard A Flavell

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Roger John Davis

7

object named as

Roger J Davis

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author name string

Wojciech Swat

2

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Sheng Zhang

3

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Zhong-Yin Zhang

4

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Benjamin G Neel

Sam68 is required for both NF-κB activation and apoptosis signaling by the TNF receptor

5

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language of work or name

English

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publication date

1 October 2011

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published in

Genes & Development

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volume

25

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page(s)

2069-78

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issue

19

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cites work

1 reference

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MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation

7 April 2017

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Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

7 April 2017

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MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines

7 April 2017

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Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins

7 April 2017

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Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

7 April 2017

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Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation

7 April 2017

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Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex

7 April 2017

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Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

7 April 2017

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Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

7 April 2017

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Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

7 April 2017

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TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

7 April 2017

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ASK1 is essential for JNK/SAPK activation by TRAF2

7 April 2017

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Vav2 is an activator of Cdc42, Rac1, and RhoA

7 April 2017

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Tyrosine phosphorylation of Vav stimulates IL-6 production in mast cells by a Rac/c-Jun N-terminal kinase-dependent pathway

7 April 2017

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Lck regulates Vav activation of members of the Rho family of GTPases

7 April 2017

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Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

7 April 2017

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Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

7 April 2017

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Mitogen-activated protein kinase pathways

7 April 2017

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The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

7 April 2017

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Src family kinases are required for integrin but not PDGFR signal transduction.

7 April 2017

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TRAF2-MLK3 interaction is essential for TNF-alpha-induced MLK3 activation

10 May 2017

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Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy

27 September 2017

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Cytokine-induced activation of mixed lineage kinase 3 requires TRAF2 and TRAF6.

27 September 2017

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The role of ubiquitin in NF-kappaB regulatory pathways.

27 September 2017

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Induction of hepatitis by JNK-mediated expression of TNF-alpha

27 September 2017

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TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death

27 September 2017

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Inflammation-activated protein kinases as targets for drug development

27 September 2017

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The Vav family: at the crossroads of signaling pathways

27 September 2017

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Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades

27 September 2017

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Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differentially modulates cytokine expression

27 September 2017

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Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

27 September 2017

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Mechanism of p38 MAP kinase activation in vivo.

27 September 2017

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Activation of the Drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3.

27 September 2017

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Tumor necrosis factor-alpha induces stress fiber formation through ceramide production: role of sphingosine kinase.

27 September 2017

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MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.

27 September 2017

1 reference

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A target for Src in mitosis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197205

An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197205

Analysis of activated GAPs and GEFs in cell lysates

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197205

Activation of the small GTPase Cdc42 by the inflammatory cytokines TNF(alpha) and IL-1, and by the Epstein-Barr virus transforming protein LMP1.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197205

Essential function for the kinase TAK1 in innate and adaptive immune responses.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197205

Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197205

JunD mediates survival signaling by the JNK signal transduction pathway.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197205

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197205

Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197205

Development of anti-TNF therapy for rheumatoid arthritis

28 November 2018

1 reference

12 December 2020

Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family

1 reference

12 December 2020

Extracellular-regulated kinase 1/2, Jun N-terminal kinase, and c-Jun are involved in NF-kappa B-dependent IL-6 expression in human monocytes

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12 December 2020

Roles of phosphatidylinositol 3-kinase and Rac in the nuclear signaling by tumor necrosis factor-alpha in rat-2 fibroblasts

1 reference

12 December 2020

Chemical genetic analysis of the time course of signal transduction by JNK

1 reference

12 December 2020

Identifiers

DOI

10.1101/GAD.17224711

1 reference

4189731

4189731

1 reference

1 reference

1 reference