Ras homolog family member A (Q7276719)

BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

4 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

3 January 2017

Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 A resolution

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

44 references

8 April 2019

The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

The armadillo protein p0071 regulates Rho signalling during cytokinesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Fam65b is a new transcriptional target of FOXO1 that regulates RhoA signaling for T lymphocyte migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

RHO binding to FAM65A regulates Golgi reorientation during cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Activation of a bacterial virulence protein by the GTPase RhoA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

The role of ezrin-associated protein network in human sperm capacitation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Arachidonic acid stimulates formation of a novel complex containing nucleolin and RhoA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

WGEF activates Rho in the Wnt-PCP pathway and controls convergent extension in Xenopus gastrulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Plk4 is required for cytokinesis and maintenance of chromosomal stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

A Salmonella typhimurium-translocated glycerophospholipid:cholesterol acyltransferase promotes virulence by binding to the RhoA protein switch regions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

A comprehensive resource of interacting protein regions for refining human transcription factor networks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Effect of cancer-associated mutations in the PlexinB1 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Distinct biological activities of C3 and ADP-ribosyltransferase-deficient C3-E174Q

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Prenylated Rab acceptor protein is a receptor for prenylated small GTPases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Structural insights into the interaction of ROCKI with the switch regions of RhoA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

MgF(3)(-) as a transition state analog of phosphoryl transfer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Advanced glycation end products increase endothelial permeability through the RAGE/Rho signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Inter-domain motions of the N-domain of the KdpFABC complex, a P-type ATPase, are not driven by ATP-induced conformational changes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Toward an understanding of the protein interaction network of the human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

WNT-3a modulates platelet function by regulating small GTPase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

The small GTPase RalA targets filamin to induce filopodia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

A Salmonella typhimurium-translocated glycerophospholipid:cholesterol acyltransferase promotes virulence by binding to the RhoA protein switch regions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Activation of a bacterial virulence protein by the GTPase RhoA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

3 references

3 January 2017

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

3 January 2017

Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

3 January 2017

Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

8 references

8 April 2019

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 A resolution

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

protein kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

protein domain specific binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

Rho GDP-dissociation inhibitor binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:C9JNR4

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

1 reference

8 April 2019

Activation of a bacterial virulence protein by the GTPase RhoA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

8 April 2019

Activation of a bacterial virulence protein by the GTPase RhoA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

endoplasmic reticulum membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

3 January 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

extrinsic component of cytoplasmic side of plasma membrane

1 reference

8 April 2019

A rho gene product in human blood platelets. I. Identification of the platelet substrate for botulinum C3 ADP-ribosyltransferase as rhoA protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

2 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells

apical junction complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

Large-scale proteomics and phosphoproteomics of urinary exosomes

extracellular exosome

3 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

3 January 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

3 January 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

1 reference

8 April 2019

Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

secretory granule membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

ficolin-1-rich granule membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

3 references

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

A rho gene product in human blood platelets. I. Identification of the platelet substrate for botulinum C3 ADP-ribosyltransferase as rhoA protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

An ECT2-centralspindlin complex regulates the localization and function of RhoA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

An ECT2-centralspindlin complex regulates the localization and function of RhoA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

intracellular membrane-bounded organelle

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

3 references

8 April 2019

Rho-GTPase-activating protein interacting with Cdc-42-interacting protein 4 homolog 2 (Rich2): a new Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase-activating protein that controls dendritic spine morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Rho-GTPase-activating protein interacting with Cdc-42-interacting protein 4 homolog 2 (Rich2): a new Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase-activating protein that controls dendritic spine morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Local, persistent activation of Rho GTPases during plasticity of single dendritic spines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

Rho-GTPase-activating protein interacting with Cdc-42-interacting protein 4 homolog 2 (Rich2): a new Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase-activating protein that controls dendritic spine morphogenesis

EXP

glutamatergic synapse

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Rho-GTPase-activating protein interacting with Cdc-42-interacting protein 4 homolog 2 (Rich2): a new Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase-activating protein that controls dendritic spine morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Local, persistent activation of Rho GTPases during plasticity of single dendritic spines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

intracellular anatomical structure

EXP

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=C9JNR4&geneProductId=UniProtKB:C9JNR4

actin cytoskeleton reorganization

biological process

1 reference

8 April 2019

Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

ossification involved in bone maturation

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

apolipoprotein A-I-mediated signaling pathway

1 reference

8 April 2019

Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

regulation of cell migration

1 reference

3 January 2017

The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

1 reference

8 April 2019

Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

regulation of actin cytoskeleton organization

1 reference

3 January 2017

Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

cleavage furrow formation

1 reference

8 April 2019

An ECT2-centralspindlin complex regulates the localization and function of RhoA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

substantia nigra development

1 reference

3 January 2017

Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

ephrin receptor signaling pathway

IEP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

endothelial tube lumen extension

1 reference

8 April 2019

DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

Roundabout signaling pathway

IGI

1 reference

8 April 2019

Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

positive regulation of axonogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement

stress fiber assembly

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

regulation of osteoblast proliferation

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

negative regulation of cell migration involved in sprouting angiogenesis

1 reference

8 April 2019

DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

positive regulation of protein serine/threonine kinase activity

IGI

1 reference

8 April 2019

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

mitotic cleavage furrow formation

1 reference

8 April 2019

An ECT2-centralspindlin complex regulates the localization and function of RhoA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10

mitotic spindle assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

negative regulation of axonogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

vascular endothelial growth factor receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

skeletal muscle satellite cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

trabecula morphogenesis

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

positive regulation of neuron differentiation

1 reference

8 April 2019

The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

positive regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

8 April 2019

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

regulation of small GTPase mediated signal transduction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

transforming growth factor beta receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells

apical junction assembly

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

wound healing, spreading of cells

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

endothelial cell migration

1 reference

8 April 2019

DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

positive regulation of stress fiber assembly

IGI

1 reference

3 January 2017

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

actin cytoskeleton organization

1 reference

3 January 2017

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P61586

phosphatidylinositol-mediated signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

regulation of cell motility

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

protein deubiquitination

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

neutrophil degranulation

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

alpha-beta T cell lineage commitment

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

regulation of systemic arterial blood pressure by endothelin

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

cytoskeleton organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

actin filament organization

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

Rho protein signal transduction

5 references

8 April 2019

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Fam65b is a new transcriptional target of FOXO1 that regulates RhoA signaling for T lymphocyte migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

skeletal muscle tissue development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

regulation of actin polymerization or depolymerization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

regulation of cell shape

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

response to mechanical stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

regulation of neuron projection development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

negative regulation of neuron projection development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

3 references

8 April 2019

Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

substantia nigra development

1 reference

8 April 2019

Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

cerebral cortex cell migration

HEP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

forebrain radial glial cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

positive regulation of cell growth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

positive regulation of cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

androgen receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

positive regulation of actin filament polymerization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

establishment or maintenance of actin cytoskeleton polarity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

stress-activated protein kinase signaling cascade

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

regulation of actin cytoskeleton organization

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

negative regulation of intracellular steroid hormone receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex

cell junction assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

negative regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement

stress fiber assembly

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

response to amino acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

negative regulation of neuron apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

positive regulation of neuron apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

establishment of epithelial cell apical/basal polarity

1 reference

8 April 2019

Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

negative regulation of neuron differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

positive regulation of translation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

positive regulation of cell adhesion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

negative regulation of cell size

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

positive regulation of vasoconstriction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

positive regulation of smooth muscle contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

GTP metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

positive regulation of alpha-beta T cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

neuron projection morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

regulation of dendrite development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

actin filament bundle assembly

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

response to glucocorticoid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

positive regulation of stress fiber assembly

regulation of focal adhesion assembly

1 reference

8 April 2019

Interaction of microglia and amyloid-beta through beta2-integrin is regulated by RhoA.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

regulation of calcium ion transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

negative regulation of cell death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

regulation of microtubule cytoskeleton organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

cellular response to lipopolysaccharide

1 reference

8 April 2019

Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

cellular response to cytokine stimulus

1 reference

8 April 2019

Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

positive regulation of podosome assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

negative regulation of oxidative phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

positive regulation of NIK/NF-kappaB signaling

negative regulation of reactive oxygen species biosynthetic process

NAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

positive regulation of vascular associated smooth muscle contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

positive regulation of leukocyte adhesion to vascular endothelial cell

1 reference

8 April 2019

Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

regulation of modification of synaptic structure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

regulation of modification of postsynaptic actin cytoskeleton

1 reference

8 April 2019

Local, persistent activation of Rho GTPases during plasticity of single dendritic spines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

cellular response to chemokine

EXP

1 reference

8 April 2019

Fam65b is a new transcriptional target of FOXO1 that regulates RhoA signaling for T lymphocyte migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

regulation of neural precursor cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

positive regulation of T cell migration

1 reference

8 April 2019

Fam65b is a new transcriptional target of FOXO1 that regulates RhoA signaling for T lymphocyte migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61586

physically interacts with

1 reference

https://thebiogrid.org/news/227

retrieved

19 April 2020

stated in

BioGRID

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

Gene Atlas image

PBB GE RHOA 200736 s at fs.png
732 × 530; 11 KB

0 references

has part(s)

small GTP-binding protein domain

2 references

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P61586

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/C9JNR4

Identifiers

MeSH descriptor ID

D020742

subject named as

rhoA GTP-Binding Protein

0 references

MeSH tree code

D08.811.277.040.330.300.400.700.200

0 references

D12.644.360.525.700.200

0 references

D12.776.157.325.515.700.200

0 references

D12.776.476.525.700.200

0 references

1 reference

30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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13 November 2019

1 reference

4 August 2016

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9 August 2016

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9 August 2016