A novel exon within the mdm2 gene modulates translation initiation in vitro and disrupts the p53-binding domain of mdm2 protein (Q73270818)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10597303%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

title

A novel exon within the mdm2 gene modulates translation initiation in vitro and disrupts the p53-binding domain of mdm2 protein (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10597303%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

author name string

N Veldhoen

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10597303%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

S Metcalfe

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10597303%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

J Milner

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10597303%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

language of work or name

English

0 references

publication date

1 November 1999

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10597303%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10597303%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

volume

18

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2 November 2019

issue

50

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2 November 2019

page(s)

7026-7033

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1203182

2 November 2019

exact match

0 references

cites work

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Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

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Molecular characterization of the hdm2-p53 interaction

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A non-AUG translational initiation event generates novel WT1 isoforms

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Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

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Mapping of the p53 and mdm-2 interaction domains

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Evidence for allosteric variants of wild-type p53, a tumour suppressor protein

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The MDM2 oncoprotein binds specifically to RNA through its RING finger domain

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7 January 2021

A genetic approach to mapping the p53 binding site in the MDM2 protein

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7 January 2021

Evidence that immunological variants of p53 represent alternative protein conformations

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Human endometrial stromal cells express novel isoforms of the transcriptional modulator CREM and up-regulate ICER in the course of decidualization

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The mdm2 proto-oncogene

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Physical and functional interaction between wild-type p53 and mdm2 proteins

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Mdm2 promotes the rapid degradation of p53

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

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Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

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7 January 2021

Genomic organization of the mouse double minute 2 gene.

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The Mdm2 oncoprotein interacts with the cell fate regulator Numb

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7 January 2021

Expression of alternatively spliced mdm2 transcripts correlates with stabilized wild-type p53 protein in human glioblastoma cells.

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7 January 2021

Keeping an old friend under control: regulation of p53 stability

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7 January 2021

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

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Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

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The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

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Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis.

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Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

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Translational termination efficiency in mammals is influenced by the base following the stop codon.

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The MDM2 gene amplification database

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Mdm-2: "big brother" of p53.

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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7 January 2021

The organization and expression of the mdm2 gene

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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7 January 2021

Amplification of a gene encoding a p53-associated protein in human sarcomas

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

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Splicing of messenger RNA precursors

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Mdm2: keeping p53 under control

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Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

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7 January 2021

Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome

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7 January 2021

Multiple murine double minute gene 2 (MDM2) proteins are induced by ultraviolet light

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7 January 2021

Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.

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7 January 2021

p53-independent role of MDM2 in TGF-beta1 resistance

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7 January 2021

Isolation of canine p53 cDNA and detailed characterization of the full length canine p53 protein

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7 January 2021

Interaction between the retinoblastoma protein and the oncoprotein MDM2

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