Ionizing radiation exposure results in up-regulation of Ku70 via a p53/ataxia-telangiectasia-mutated protein-dependent mechanism (Q73487453)

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4 November 2019

title

Ionizing radiation exposure results in up-regulation of Ku70 via a p53/ataxia-telangiectasia-mutated protein-dependent mechanism (English)

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4 November 2019

author name string

K D Brown

1

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4 November 2019

T A Lataxes

2

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4 November 2019

S Shangary

3

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4 November 2019

J L Mannino

4

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4 November 2019

J F Giardina

5

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4 November 2019

J Chen

6

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4 November 2019

R Baskaran

7

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4 November 2019

language of work or name

English

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publication date

1 March 2000

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Journal of Biological Chemistry

4 November 2019

published in

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4 November 2019

volume

275

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4 November 2019

issue

9

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4 November 2019

page(s)

6651-6656

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Regulation of p53 downstream genes.

4 November 2019

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Relationship of the ataxia-telangiectasia protein ATM to phosphoinositide 3-kinase

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Multiple ATM-dependent pathways: an explanation for pleiotropy

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Mutagenicity and cytotoxicity of haloethanes as studied in the CHO/HGPRT system

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Defect in multiple cell cycle checkpoints in ataxia-telangiectasia postirradiation

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Effect of confluent holding on potentially lethal damage repair, cell cycle progression, and chromosomal aberrations in human normal and ataxia-telangiectasia fibroblasts

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

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Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways.

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Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

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The ionizing radiation-induced replication protein A phosphorylation response differs between ataxia telangiectasia and normal human cells

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DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair

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Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.

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DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect

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DNA-dependent protein kinase-independent activation of p53 in response to DNA damage

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DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage

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The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

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Activation of an MDM2-specific caspase by p53 in the absence of apoptosis

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Expression, localization and functional interactions of Ku70 subunit of DNA-PK in peripheral lymphocytes and Nalm-19 cells after irradiation

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Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

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ATM: from gene to function

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Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

21 January 2018

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KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion

21 January 2018

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KARP-1: a novel leucine zipper protein expressed from the Ku86 autoantigen locus is implicated in the control of DNA-dependent protein kinase activity

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Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo

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Identifiers

DOI

10.1074/JBC.275.9.6651

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10692474%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

1 reference