Beta-secretase revealed: starting gate for race to novel therapies for Alzheimer's disease (Q73721783)

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6 November 2019

title

Beta-secretase revealed: starting gate for race to novel therapies for Alzheimer's disease (English)

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6 November 2019

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D M Skovronsky

1

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6 November 2019

V M Lee

series ordinal

2

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6 November 2019

publication date

1 May 2000

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Trends in Pharmacological Sciences

6 November 2019

published in

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6 November 2019

volume

21

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6 November 2019

page(s)

161-163

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6 November 2019

issue

5

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

6 November 2019

cites work

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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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7 January 2021

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

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7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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7 January 2021

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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7 January 2021

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7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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7 January 2021

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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7 January 2021

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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7 January 2021

The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein

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7 January 2021

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

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7 January 2021

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

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7 January 2021

Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells

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7 January 2021

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides

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7 January 2021

Differential effects of the swedish mutant amyloid precursor protein on beta-amyloid accumulation and secretion in neurons and nonneuronal cells

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7 January 2021

Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture

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7 January 2021

Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

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7 January 2021

10.1016/S0165-6147(00)01467-X

Identifiers

DOI

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6 November 2019

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