Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition (Q77879066)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10367901%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

title

Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition (English)

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8 December 2019

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1

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8 December 2019

F. Susan Wong

series ordinal

2

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8 December 2019

3

C A Janeway

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8 December 2019

publication date

1 May 1999

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8 December 2019

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8 December 2019

volume

10

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8 December 2019

page(s)

559-568

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8 December 2019

issue

5

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Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus

8 December 2019

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In thymic selection, peptide diversity gives and takes away

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Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression

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Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells

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Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides

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HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading

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Thymic selection and cell division

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Deficient Positive Selection of CD4 T Cells in Mice Displaying Altered Repertoires of MHC Class II–Bound Self-Peptides

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Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture

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Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad

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Positive selection of thymocytes

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Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules

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In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

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Determination of lymphocyte division by flow cytometry

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7 January 2021

H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection

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Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway

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A novel MHC class II epitope expressed in thymic medulla but not cortex

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Antigen receptor signaling gives lymphocytes a long life

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Role of self-peptides in positively selecting the T-cell repertoire

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Negative selection of lymphocytes

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7 January 2021

Selective events in T cell development

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7 January 2021

Peripheral selection of the T cell repertoire

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7 January 2021

Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses

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Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype

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7 January 2021

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Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ T cells.

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7 January 2021

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

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7 January 2021

The peripheral T cell repertoire: independent homeostatic regulation of virgin and activated CD8+ T cell pools

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7 January 2021

Peripheral selection of T cell repertoires: the role of continuous thymus output

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7 January 2021

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Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10367901%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

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