The 99 and 170 loop-modified factor VIIa mutants show enhanced catalytic activity without tissue factor (Q78327619)

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13 December 2019

title

The 99 and 170 loop-modified factor VIIa mutants show enhanced catalytic activity without tissue factor (English)

1 reference

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13 December 2019

author name string

Kenji Soejima

1

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13 December 2019

Masato Yuguchi

2

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13 December 2019

Jun Mizuguchi

3

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13 December 2019

Kazuhiko Tomokiyo

4

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13 December 2019

Toshihiro Nakashima

5

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13 December 2019

Tomohiro Nakagaki

6

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13 December 2019

Sadaaki Iwanaga

7

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13 December 2019

language of work or name

English

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publication date

2 October 2002

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Journal of Biological Chemistry

13 December 2019

published in

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13 December 2019

volume

277

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13 December 2019

issue

50

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13 December 2019

page(s)

49027-49035

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The coagulation cascade: initiation, maintenance, and regulation

13 December 2019

cites work

1 reference

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Characterization of a cDNA coding for human factor VII

21 January 2018

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The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

21 January 2018

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Structure of human factor VIIa and its implications for the triggering of blood coagulation

21 January 2018

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Crystal structure of active site-inhibited human coagulation factor VIIa (des-Gla)

21 January 2018

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The factor VII zymogen structure reveals reregistration of beta strands during activation

21 January 2018

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Peptide exosite inhibitors of factor VIIa as anticoagulants

21 January 2018

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Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant

21 January 2018

1 reference

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Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold

21 January 2018

1 reference

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Structure of human des(1-45) factor Xa at 2.2 A resolution

21 January 2018

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X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition

21 January 2018

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Structural basis for chemical inhibition of human blood coagulation factor Xa

21 January 2018

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X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B

21 January 2018

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Converting blood coagulation factor IXa into factor Xa: dramatic increase in amidolytic activity identifies important active site determinants

21 January 2018

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Molecular and structural advances in tissue factor-dependent coagulation

21 January 2018

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Factor IXa:factor VIIIa interaction. helix 330-338 of factor ixa interacts with residues 558-565 and spatially adjacent regions of the a2 subunit of factor VIIIa

21 January 2018

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Human beta-tryptase is a ring-like tetramer with active sites facing a central pore

21 January 2018

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Initiation of the extrinsic pathway of blood coagulation: evidence for the tissue factor dependent autoactivation of human coagulation factor VII.

21 January 2018

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A convenient protein substrate for the determination of protease specificity: reduced and S-3-(trimethylated amino)propylated lysozyme

21 January 2018

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Factor VIIa modified in the 170 loop shows enhanced catalytic activity but does not change the zymogen-like property

21 January 2018

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Proteolytic activation of human factors IX and X by recombinant human factor VIIa: effects of calcium, phospholipids, and tissue factor

21 January 2018

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Incorporation of an active site inhibitor in factor VIIa alters the affinity for tissue factor

21 January 2018

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Molecular mechanism of tissue factor-mediated acceleration of factor VIIa activity

21 January 2018

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New enzyme lineages by subdomain shuffling

21 January 2018

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Insertion loop 256-268 in coagulation factor IX restricts enzymatic activity in the absence but not in the presence of factor VIII

21 January 2018

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Substitution of valine for leucine 305 in factor VIIa increases the intrinsic enzymatic activity.

21 January 2018

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Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity.

21 January 2018

1 reference

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Conformation of factor VIIa stabilized by a labile disulfide bond (Cys-310-Cys-329) in the protease domain is essential for interaction with tissue factor

21 January 2018

1 reference

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New insight into how tissue factor allosterically regulates factor VIIa

21 January 2018

1 reference

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Residue Met(156) contributes to the labile enzyme conformation of coagulation factor VIIa

21 January 2018

1 reference

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Role of residue Phe225 in the cofactor-mediated, allosteric regulation of the serine protease coagulation factor VIIa

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M203091200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12364340%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

1 reference