vascular endothelial growth factor A (Q7916455)

Vascular endothelial growth factor, heparin-binding domain superfamily

1 reference

Vascular endothelial growth factor, heparin-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PDGF/VEGF domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Platelet-derived growth factor, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

2 references

13 November 2019

17 September 2016

2 references

13 November 2019

20 March 2016

pH regulates vascular endothelial growth factor binding to fibronectin: a mechanism for control of extracellular matrix storage and release

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Heparin affin regulatory peptide binds to vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

extracellular matrix binding

1 reference

8 April 2019

pH regulates vascular endothelial growth factor binding to fibronectin: a mechanism for control of extracellular matrix storage and release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

IC

growth factor activity

5 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Vasoactive peptides modulate vascular endothelial cell growth factor production and endothelial cell proliferation and invasion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

1 reference

5 June 2018

Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

vascular endothelial growth factor receptor 2 binding

3 references

5 June 2018

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

receptor ligand activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

vascular endothelial growth factor receptor 1 binding

1 reference

5 June 2018

The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

protein homodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

platelet-derived growth factor receptor binding

1 reference

8 April 2019

Vascular endothelial growth factor can signal through platelet-derived growth factor receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 references

8 April 2019

MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Early VEGFR2 activation in response to flow is VEGF-dependent and mediated by MMP activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Endorepellin laminin-like globular 1/2 domains bind Ig3-5 of vascular endothelial growth factor (VEGF) receptor 2 and block pro-angiogenic signaling by VEGFA in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

vascular endothelial growth factor receptor binding

3 references

5 June 2018

Characterization of the VEGF binding site on the Flt-1 receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

1 reference

8 April 2019

pH regulates vascular endothelial growth factor binding to fibronectin: a mechanism for control of extracellular matrix storage and release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

Expression and functions of the vascular endothelial growth factors and their receptors in human basophils

chemoattractant activity

6 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

protein heterodimerization activity

1 reference

8 April 2019

Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

vascular endothelial growth factor receptor binding

3 references

8 April 2019

Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Characterization of the VEGF binding site on the Flt-1 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

growth factor activity

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Vasoactive peptides modulate vascular endothelial cell growth factor production and endothelial cell proliferation and invasion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

Expression and functions of the vascular endothelial growth factors and their receptors in human basophils

chemoattractant activity

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

vascular endothelial growth factor receptor 2 binding

4 references

8 April 2019

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:H0YBI8

1 reference

8 April 2019

Expression and functions of the vascular endothelial growth factors and their receptors in human basophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:H0YBI8

1 reference

8 April 2019

Vascular endothelial growth factor can signal through platelet-derived growth factor receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

1 reference

8 April 2019

Expression and functions of the vascular endothelial growth factors and their receptors in human basophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

platelet alpha granule lumen

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

3 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Hypoxic conditions stimulate the production of angiogenin and vascular endothelial growth factor by human renal proximal tubular epithelial cells in culture

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Vasoactive peptides modulate vascular endothelial cell growth factor production and endothelial cell proliferation and invasion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

1 reference

8 April 2019

pH regulates vascular endothelial growth factor binding to fibronectin: a mechanism for control of extracellular matrix storage and release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Hypoxic conditions stimulate the production of angiogenin and vascular endothelial growth factor by human renal proximal tubular epithelial cells in culture

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Vasoactive peptides modulate vascular endothelial cell growth factor production and endothelial cell proliferation and invasion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

cardiac vascular smooth muscle cell development

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of protein phosphorylation

positive regulation of MAP kinase activity

1 reference

8 April 2019

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of receptor internalization

1 reference

8 April 2019

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

outflow tract morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

mammary gland alveolus development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions

monocyte differentiation

1 reference

8 April 2019

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

1 reference

8 April 2019

Vasculogenesis and angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of retinal ganglion cell axon guidance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

vascular endothelial growth factor receptor signaling pathway

3 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

positive regulation of vascular permeability

1 reference

5 June 2018

Transgenic overexpression of vascular endothelial growth factor-B isoforms by endothelial cells potentiates postnatal vessel growth in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

positive regulation of mesenchymal cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

3 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Vascular endothelial growth factor induces cyclooxygenase-dependent proliferation of endothelial cells via the VEGF-2 receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

positive regulation of blood vessel endothelial cell migration

3 references

8 April 2019

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Vasoactive peptides modulate vascular endothelial cell growth factor production and endothelial cell proliferation and invasion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of ERK1 and ERK2 cascade

1 reference

5 June 2018

The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of p38MAPK cascade

1 reference

8 April 2019

Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of neuroblast proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

dopaminergic neuron differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of branching involved in ureteric bud morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

coronary artery morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

in utero embryonic development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

commissural neuron axon guidance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of peptidyl-serine phosphorylation

positive regulation of CREB transcription factor activity

1 reference

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

1 reference

5 June 2018

Expression and functions of the vascular endothelial growth factors and their receptors in human basophils

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

regulation of transcription from RNA polymerase II promoter in response to hypoxia

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of peptidyl-tyrosine autophosphorylation

1 reference

8 April 2019

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of peptidyl-tyrosine phosphorylation

3 references

8 April 2019

Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

branching involved in blood vessel morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of protein localization to early endosome

1 reference

5 June 2018

The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

primitive erythrocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of protein kinase D signaling

1 reference

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

epithelial cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of leukocyte migration

1 reference

8 April 2019

The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of epithelial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

negative regulation of apoptotic process

negative regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

nervous system development

1 reference

8 April 2019

VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

macrophage differentiation

1 reference

8 April 2019

Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of angiogenesis

6 references

5 June 2018

Aquaporin 1 is required for hypoxia-inducible angiogenesis in human retinal vascular endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

The effects of growth factors on the proliferation and in vitro angiogenesis of human macular inner choroidal endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

regulation of retinal ganglion cell axon guidance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

lymph vessel morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

post-embryonic camera-type eye development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

ovarian follicle development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

branching morphogenesis of an epithelial tube

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

coronary vein morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

surfactant homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of vascular endothelial growth factor receptor signaling pathway

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

1 reference

5 June 2018

Hypoxic conditions stimulate the production of angiogenin and vascular endothelial growth factor by human renal proximal tubular epithelial cells in culture

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

positive regulation of endothelial cell proliferation

8 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Expression and Localization of Tenomodulin, a Transmembrane Type Chondromodulin-I-Related Angiogenesis Inhibitor, in Mouse Eyes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Vasoactive peptides modulate vascular endothelial cell growth factor production and endothelial cell proliferation and invasion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

The effects of growth factors on the proliferation and in vitro angiogenesis of human macular inner choroidal endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

positive regulation of protein-containing complex assembly

positive regulation of protein kinase C signaling

1 reference

8 April 2019

The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

platelet degranulation

1 reference

8 April 2019

positive regulation of axon extension involved in axon guidance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of endothelial cell migration

multicellular organism development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of histone deacetylase activity

1 reference

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

1 reference

8 April 2019

AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of gene expression

1 reference

8 April 2019

Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of protein autophosphorylation

1 reference

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

endothelial cell chemotaxis

1 reference

8 April 2019

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

1 reference

8 April 2019

Vascular endothelial growth factor can signal through platelet-derived growth factor receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway

3 references

8 April 2019

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

eye photoreceptor cell development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

1 reference

8 April 2019

Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of focal adhesion assembly

1 reference

8 April 2019

Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

cellular response to vascular endothelial growth factor stimulus

positive regulation of cell division

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

camera-type eye morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of transcription by RNA polymerase II

positive regulation of cell adhesion

1 reference

8 April 2019

Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

cellular response to hypoxia

1 reference

8 April 2019

Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of cell population proliferation

induction of positive chemotaxis

3 references

5 June 2018

Vascular endothelial growth factor is a chemoattractant for trophoblast cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

motor neuron migration

1 reference

8 April 2019

positive regulation of tyrosine phosphorylation of STAT protein

1 reference

8 April 2019

Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

positive regulation of phosphorylation

1 reference

5 June 2018

Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692

negative regulation of gene expression

1 reference

8 April 2019

MicroRNA-30b controls endothelial cell capillary morphogenesis through regulation of transforming growth factor beta 2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

cytokine-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of cell migration involved in sprouting angiogenesis

3 references

8 April 2019

Dysregulated miR-361-5p/VEGF axis in the plasma and endothelial progenitor cells of patients with coronary artery disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

cellular stress response to acid chemical

1 reference

8 April 2019

High concentrations of uric acid inhibit angiogenesis via regulation of the Krüppel-like factor 2-vascular endothelial growth factor-A axis by miR-92a

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

1 reference

8 April 2019

Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of sprouting angiogenesis

IGI

positive regulation of DNA biosynthetic process

IGI

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Vascular endothelial growth factor induces cyclooxygenase-dependent proliferation of endothelial cells via the VEGF-2 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of protein phosphorylation

3 references

8 April 2019

AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of endothelial cell proliferation

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Expression and Localization of Tenomodulin, a Transmembrane Type Chondromodulin-I-Related Angiogenesis Inhibitor, in Mouse Eyes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

The effects of growth factors on the proliferation and in vitro angiogenesis of human macular inner choroidal endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Vasoactive peptides modulate vascular endothelial cell growth factor production and endothelial cell proliferation and invasion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

sprouting angiogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

regulation of nitric oxide mediated signal transduction

1 reference

8 April 2019

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

vascular endothelial growth factor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

VEGF-activated neuropilin signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of angiogenesis

6 references

8 April 2019

Aquaporin 1 is required for hypoxia-inducible angiogenesis in human retinal vascular endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

The effects of growth factors on the proliferation and in vitro angiogenesis of human macular inner choroidal endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

vascular endothelial growth factor receptor signaling pathway

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

1 reference

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of mast cell chemotaxis

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

positive regulation of cold-induced thermogenesis

1 reference

8 April 2019

Autocrine effect of vascular endothelial growth factor-A is essential for mitochondrial function in brown adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:H0YBI8

physically interacts with

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3707357

Gene Atlas image

PBB GE VEGFA 210512 s at.png
255 × 135; 844 bytes

1 reference

imported from Wikimedia project

English Wikipedia

has part(s)

Platelet-derived growth factor, conserved site

2 references

PDGF/VEGF domain

2 references

Vascular endothelial growth factor, heparin-binding domain

2 references

Identifiers

MeSH descriptor ID

D042461

subject named as

Vascular Endothelial Growth Factor A

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MeSH tree code

D12.644.276.100.800.200

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D12.776.467.100.800.200

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30 May 2020

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13 November 2019

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20 March 2016

https://docs.openalex.org/download-snapshot/snapshot-data-format

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Microsoft Academic ID

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26 January 2022

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