IL-12 up-regulates T-bet independently of IFN-gamma in human CD4+ T cells (Q81342452)

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8 January 2020

title

IL-12 up-regulates T-bet independently of IFN-gamma in human CD4+ T cells (English)

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8 January 2020

2

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8 January 2020

Minna K Kyläniemi

3

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7

Riitta Lahesmaa

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8 January 2020

1

Emmi Ylikoski

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8 January 2020

author name string

Sanna Filén

4

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8 January 2020

Maritta Kilpeläinen

5

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8 January 2020

Johannes Savolainen

6

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8 January 2020

publication date

1 November 2005

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European Journal of Immunology

8 January 2020

published in

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8 January 2020

volume

35

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issue

11

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8 January 2020

page(s)

3297-3306

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An interleukin-4-induced transcription factor: IL-4 Stat

8 January 2020

cites work

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7 January 2021

Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

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7 January 2021

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4

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7 January 2021

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

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7 January 2021

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

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7 January 2021

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells

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7 January 2021

Essential role of Stat6 in IL-4 signalling

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7 January 2021

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

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7 January 2021

Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

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7 January 2021

Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile

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7 January 2021

Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.

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7 January 2021

Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.

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7 January 2021

A novel transcription factor, T-bet, directs Th1 lineage commitment

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7 January 2021

Peroxisome proliferator-activated receptor alpha negatively regulates T-bet transcription through suppression of p38 mitogen-activated protein kinase activation

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7 January 2021

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

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7 January 2021

T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells

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7 January 2021

IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response

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7 January 2021

IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells

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7 January 2021

Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment

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7 January 2021

IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms

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7 January 2021

IL-27 and IFN-αSignal via Stat1 and Stat3 and Induce T-Bet and IL-12Rβ2 in Naive T Cells

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7 January 2021

Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells

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7 January 2021

Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene

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7 January 2021

The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

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7 January 2021

Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3

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7 January 2021

GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet

1 reference

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7 January 2021

Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities☆

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7 January 2021

T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

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7 January 2021

Sustained IL-12 signaling is required for Th1 development

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7 January 2021

Transforming growth factor-beta in T-cell biology

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7 January 2021

Cutting edge: TGF-beta inhibits Th type 2 development through inhibition of GATA-3 expression.

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7 January 2021

Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation

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7 January 2021

The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease

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7 January 2021

TGF-β1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression

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7 January 2021

Kinetics of GATA-3 gene expression in early polarizing and committed human T cells

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7 January 2021

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling.

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7 January 2021

Identification of novel genes regulated by IL-12, IL-4, or TGF-beta during the early polarization of CD4+ lymphocytes

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7 January 2021

Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes

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7 January 2021

Early target genes of IL-12 and STAT4 signaling in th cells.

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7 January 2021

Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells

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7 January 2021

Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level

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7 January 2021

Signaling lymphocytic activation molecule (SLAM) is differentially expressed in human Th1 and Th2 cells

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7 January 2021

Identification and validation of endogenous reference genes for expression profiling of T helper cell differentiation by quantitative real-time RT-PCR

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7 January 2021

Identifiers

DOI

10.1002/EJI.200526101

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16220539%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference