mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: identification of IL-20 receptor-mediated bystander activity against pancreatic cancer (Q81684243)

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scientific article published on 01 May 2005

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English	mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: identification of IL-20 receptor-mediated bystander activity against pancreatic cancer	scientific article published on 01 May 2005

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scholarly article

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11 January 2020

mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: identification of IL-20 receptor-mediated bystander activity against pancreatic cancer (English)

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11 January 2020

pancreatic cancer

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based on heuristic

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Sunil Chada

1

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Dora Bocangel

2

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11 January 2020

Rajagopal Ramesh

3

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11 January 2020

Elizabeth A Grimm

4

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John B Mumm

5

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Abner M Mhashilkar

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Mingzhong Zheng

7

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publication date

1 May 2005

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Molecular Therapy

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11

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5

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724-733

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11 January 2020

Apoptosis: targets in pancreatic cancer

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Melanoma differentiation associated gene-7 (mda-7): a novel anti-tumor gene for cancer gene therapy

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The melanoma differentiation associated gene mda-7 suppresses cancer cell growth

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Ectopic production of MDA-7/IL-24 inhibits invasion and migration of human lung cancer cells

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Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro

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Down-regulated melanoma differentiation associated gene (mda-7) expression in human melanomas

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The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice

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Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo

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Loss of MDA-7 expression with progression of melanoma

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Combination therapy of Ad-mda7 and trastuzumab increases cell death in Her-2/neu-overexpressing breast cancer cells

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Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study

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Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): biologic outcome in advanced cancer patients

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Adenovirus-mediated mda-7 (IL24) gene therapy suppresses angiogenesis and sensitizes NSCLC xenograft tumors to radiation

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Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner

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Adenoviral melanoma differentiation-associated gene 7 induces apoptosis in lung cancer cells through mitochondrial permeability transition-independent cytochrome c release

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The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24.

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The tumor suppressor activity of MDA-7/IL-24 is mediated by intracellular protein expression in NSCLC cells

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Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells

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Inhibition of AKT abrogates chemotherapy-induced NF-kappaB survival mechanisms: implications for therapy in pancreatic cancer

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Role of the phosphatidylinositol 3'-kinase-Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines

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Dysregulation of beta-catenin expression correlates with tumor differentiation in pancreatic duct adenocarcinoma

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7 January 2021

MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast and lung tumor cells

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Bystander activity of Ad-mda7: human MDA-7 protein kills melanoma cells via an IL-20 receptor-dependent but STAT3-independent mechanism

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1 reference

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7 January 2021

MDA-7/IL-24 is a unique cytokine--tumor suppressor in the IL-10 family.

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7 January 2021

Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties

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7 January 2021

A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells

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Reciprocal enhancement of gene transfer by combinatorial adenovirus transduction and plasmid DNA transfection in vitro and in vivo.

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Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2.

1 reference

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Identifiers

10.1016/J.YMTHE.2004.12.021

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11 January 2020

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11 January 2020

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