Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance (Q82678814)

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17 January 2020

title

Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance (English)

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17 January 2020

6

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17 January 2020

author name string

Nancy Hakooz

1

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17 January 2020

Kiyomi Ito

2

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17 January 2020

Helen Rawden

3

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17 January 2020

Helen Gill

4

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17 January 2020

Lynn Lemmers

5

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17 January 2020

Robert J Edwards

7

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17 January 2020

David J Carlile

8

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Brian G Lake

9

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J Brian Houston

10

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publication date

28 February 2006

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17 January 2020

published in

Pharmaceutical Research

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17 January 2020

volume

23

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issue

3

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page(s)

533-539

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Cytochrome P-450 measurement in rat liver homogenate and microsomes. Its use for correction of microsomal losses incurred by differential centrifugation

17 January 2020

cites work

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12 December 2020

Variance of microsomal protein and cytochrome P450 2E1 and 3A forms in adult human liver

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12 December 2020

Microsomal prediction ofin vivoclearance and associated interindividual variability of six benzodiazepines in humans

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12 December 2020

In vivo pharmacokinetics of felodipine predicted from in vitro studies in rat, dog and man

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12 December 2020

Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes

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12 December 2020

THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

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12 December 2020

Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes

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12 December 2020

Microsomal cytochrome P-450-linked monooxygenase systems and lipid composition of human hepatocellular carcinoma

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12 December 2020

Effects of age and gender on in vitro properties of human liver microsomal monooxygenases

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12 December 2020

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

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12 December 2020

Changes in liver volume from birth to adulthood: a meta-analysis.

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12 December 2020

Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans

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12 December 2020

Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport

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12 December 2020

Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: studies with induced livers involving diazepam.

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12 December 2020

Role of pharmacokinetics and metabolism in drug discovery and development

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12 December 2020

Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

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12 December 2020

Drug metabolism in human liver in vitro: establishment of a human liver bank.

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12 December 2020

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

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12 December 2020

In vitro to in vivo extrapolation for trichloroethylene metabolism in humans.

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12 December 2020

Inter-individual variability in levels of human microsomal protein and hepatocellularity per gram of liver

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12 December 2020

Effects of freezing, thawing, and storing human liver microsomes on cytochrome P450 activity.

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12 December 2020

Protein measurement with the Folin phenol reagent

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12 December 2020

Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans

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12 December 2020

Characterization of Phase I and Phase II hepatic drug metabolism activities in a panel of human liver preparations

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12 December 2020

Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

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12 December 2020

The prediction of human clearance from hepatic microsomal metabolism data

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12 December 2020

Irreversible binding and metabolism of propranolol by human liver microsomes--relationship to polymorphic oxidation

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12 December 2020

10.1007/S11095-006-9531-2

Identifiers

DOI

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17 January 2020

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