Ciliary neurotrophic factor (CNTF) protects non-obese Swiss mice against type 2 diabetes by increasing beta cell mass and reducing insulin clearance (Q83473619)

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scientific article published on 19 February 2012

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English	Ciliary neurotrophic factor (CNTF) protects non-obese Swiss mice against type 2 diabetes by increasing beta cell mass and reducing insulin clearance	scientific article published on 19 February 2012

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22349107%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Ciliary neurotrophic factor (CNTF) protects non-obese Swiss mice against type 2 diabetes by increasing beta cell mass and reducing insulin clearance (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22349107%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

type 2 diabetes

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Gustavo J Santos

2

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Europe PubMed Central

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23 January 2020

author name string

L F Rezende

1

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23 January 2020

J C Santos-Silva

3

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23 January 2020

E M Carneiro

4

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23 January 2020

A C Boschero

5

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23 January 2020

publication date

19 February 2012

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23 January 2020

1 reference

Europe PubMed Central

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23 January 2020

55

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23 January 2020

5

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23 January 2020

1495-1504

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23 January 2020

https://scigraph.springernature.com/pub.10.1007/s00125-012-2493-5

0 references

Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative study of insulin secretion and clearance in normal and obese subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High doses of dexamethasone induce increased beta-cell proliferation in pancreatic rat islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

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Ciliary neurotrophic factor (CNTF) signals through STAT3-SOCS3 pathway and protects rat pancreatic islets from cytokine-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of portal free fatty acid elevation on insulin clearance and hepatic glucose flux

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of systemic administration of ciliary neurotrophic factor on Bax and Bcl-2 proteins in the lumbar spinal cord of neonatal rats after sciatic nerve transection

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

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Ciliary neurotrophic factor promotes survival of neonatal rat islets via the BCL-2 anti-apoptotic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant variant of ciliary neurotrophic factor for weight loss in obese adults: a randomized, dose-ranging study

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ciliary neurotrophic factor potentiates the beta-cell inhibitory effect of IL-1beta in rat pancreatic islets associated with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in the glucose-stimulated insulin secretory dose-response curve and in insulin clearance in nondiabetic insulin-resistant individuals.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ciliary neurotrophic factor infused intracerebroventricularly shows reduced catabolic effects when linked to the TAT protein transduction domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin metabolism by liver, muscle, and kidneys from spontaneously diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin clearance in obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced insulin clearance contributes to the increased insulin levels after administration of glucagon-like peptide 1 in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

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Free fatty acids impair hepatic insulin extraction in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

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Regulation of tissue inhibitor of metalloproteinases-1 gene expression by cytokines and dexamethasone in rat hepatocyte primary cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose inhibits the insulin-induced activation of the insulin-degrading enzyme in HepG2 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

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A new diabetes model induced by neonatal alloxan treatment in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

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Reduced insulin clearance in normal subjects due to extreme hyperinsulinemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ciliary neurotrophic factor receptor alpha subunit-modulated multiple downstream signaling pathways in hepatic cancer cell lines and their biological implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of liver fat on insulin clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin clearance and diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of apoptosis in pancreatic beta-cell death in diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overcoming insulin resistance with CNTF

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The regulation and activation of ciliary neurotrophic factor signaling proteins in adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The novel mechanism of recombinant human ciliary neurotrophic factor on the anti-diabetes activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

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Calcium/calmodulin-dependent protein kinase II: an unforgettable kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CNTF protects MIN6 cells against apoptosis induced by Alloxan and IL-1β through downregulation of the AMPK pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type 1 diabetes: etiology, immunology, and therapeutic strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-degrading enzyme: structure-function relationship and its possible roles in health and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ciliary neurotrophic factorAx15 alters energy homeostasis, decreases body weight, and improves metabolic control in diet-induced obese and UCP1-DTA mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-cell mass plasticity in type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

gp130 receptor ligands as potential therapeutic targets for obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type 2 diabetes-a matter of beta-cell life and death?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ciliary neurotrophic factor stimulates muscle glucose uptake by a PI3-kinase-dependent pathway that is impaired with obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered levels of adiponectin and adiponectin receptors may underlie the effect of ciliary neurotrophic factor (CNTF) to enhance insulin sensitivity in diet-induced obese mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 family of cytokines and gp130

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CNTF: a target therapeutic for obesity-related metabolic disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced hepatic insulin clearance in rats with dietary-induced obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased hepatic insulin extraction precedes overt noninsulin dependent (Type II) diabetes in obese monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in immunoreactive proinsulin and insulin clearance induced by weight loss in NIDDM.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin degradation: progress and potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/22349107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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