Sitagliptin reduces inflammation, fibrosis and preserves diastolic function in a rat model of heart failure with preserved ejection fraction (Q88911120)

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scientific article published on 21 March 2017

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English	Sitagliptin reduces inflammation, fibrosis and preserves diastolic function in a rat model of heart failure with preserved ejection fraction	scientific article published on 21 March 2017

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29 March 2020

Sitagliptin reduces inflammation, fibrosis and preserves diastolic function in a rat model of heart failure with preserved ejection fraction (English)

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Heart failure with preserved ejection fraction

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ejection fraction

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Konrad Urbanek

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Grazia Esposito

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Donato Cappetta

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Rosa Russo

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Alessia Rivellino

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Loreta Pia Ciuffreda

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Fiorentina Roviezzo

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Elena Piegari

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Liberato Berrino

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Francesco Rossi

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Antonella De Angelis

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21 March 2017

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British Journal of Pharmacology

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describes a project that uses

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Experimental design and analysis and their reporting: new guidance for publication in BJP.

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Circulating dipeptidyl peptidase IV activity correlates with cardiac dysfunction in human and experimental heart failure.

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Rosiglitazone reduces the inflammatory response in a model of vascular injury in rats.

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A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice.

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Long-term administration of ranolazine attenuates diastolic dysfunction and adverse myocardial remodeling in a model of heart failure with preserved ejection fraction.

1 reference

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Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction.

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Cardiovascular determinants of life span.

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The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries.

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Dipeptidyl peptidase inhibition prevents diastolic dysfunction and reduces myocardial fibrosis in a mouse model of Western diet induced obesity

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Differences in biochemical and genetic biomarkers in patients with heart failure of various etiologies.

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2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribut

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Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat)

1 reference

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1 reference

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Effect of dipeptidyl peptidase 4 inhibition on arterial blood pressure is context dependent

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Time-course changes in left ventricular geometry and function during the development of hypertension in Dahl salt-sensitive rats

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction.

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl Peptidase-4 Regulation of SDF-1/CXCR4 Axis: Implications for Cardiovascular Disease

1 reference

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Emerging cardiovascular actions of the incretin hormone glucagon-like peptide-1: potential therapeutic benefits beyond glycaemic control?

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The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha.

1 reference

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12 December 2020

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Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation

1 reference

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based on heuristic

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Sitagliptin reduces plaque macrophage content and stabilises arteriosclerotic lesions in Apoe (-/-) mice.

1 reference

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12 December 2020

based on heuristic

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Interleukin-12 enhances CD26 expression and dipeptidyl peptidase IV function on human activated lymphocytes

1 reference

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based on heuristic

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Dipeptidylpeptidase inhibition is associated with improvement in blood pressure and diastolic function in insulin-resistant male Zucker obese rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SIRT1 activation attenuates diastolic dysfunction by reducing cardiac fibrosis in a model of anthracycline cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiomyocyte Stiffness in Diastolic Heart Failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

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based on heuristic

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Age-dependent salt hypertension in Dahl rats: fifty years of research.

1 reference

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12 December 2020

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Stimulation of the expression and the enzyme activity of aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 on human renal cell carcinoma cells and renal tubular epithelial cells by T cell-derived cytokines, such as IL-4 and IL-13

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Murine models of diastolic dysfunction and heart failure with preserved ejection fraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

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based on heuristic

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1 reference

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based on heuristic

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The contributions of dipeptidyl peptidase IV to inflammation in heart failure.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

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How do patients with heart failure with preserved ejection fraction die?

1 reference

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12 December 2020

based on heuristic

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Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction.

1 reference

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based on heuristic

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incremental prognostic significance of peripheral endothelial dysfunction in patients with heart failure with normal left ventricular ejection fraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl peptidase-4 modulates left ventricular dysfunction in chronic heart failure via angiogenesis-dependent and -independent actions

1 reference

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based on heuristic

inferred from PubMed ID database lookup

MK-0626, a dipeptidyl peptidase-4 inhibitor, improves neovascularization by increasing both the number of circulating endothelial progenitor cells and endothelial nitric oxide synthetase expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

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based on heuristic

inferred from PubMed ID database lookup

Heart failure with preserved ejection fraction in hypertension

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: a report from the OPTIMIZE-HF Registry

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of different phenotypes of hypertensive heart failure: systolic versus diastolic failure in Dahl salt-sensitive rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

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1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heart failure with preserved ejection fraction: clinical characteristics of 4133 patients enrolled in the I-PRESERVE trial.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low myocardial protein kinase G activity in heart failure with preserved ejection fraction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

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Cyclic GMP-dependent signaling in cardiac myocytes

1 reference

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12 December 2020

based on heuristic

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1 reference

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1 reference

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12 December 2020

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The Concise Guide to PHARMACOLOGY 2015/16: Overview

1 reference

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based on heuristic

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Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure

1 reference

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12 December 2020

based on heuristic

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1 reference

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12 December 2020

based on heuristic

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential role of dipeptidyl peptidase IV in the pathophysiology of heart failure

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat-Fed Diabetic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon-gamma induces dipeptidylpeptidase IV expression in human glomerular epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl-peptidase IV inhibition improves pathophysiology of heart failure and increases survival rate in pressure-overloaded mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic glucagon-like peptide-1 infusion sustains left ventricular systolic function and prolongs survival in the spontaneously hypertensive, heart failure-prone rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heart failure with preserved ejection fraction: current understanding and emerging concepts

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase G signaling in cardiac pathophysiology: Impact of proteomics on clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sitagliptin and the risk of hospitalization for heart failure: a population-based study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sitagliptin and cardiovascular outcomes in diabetic patients with chronic kidney disease and acute myocardial infarction: A nationwide cohort study

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation and oxidative stress caused by nitric oxide synthase uncoupling might lead to left ventricular diastolic and systolic dysfunction in patients with hypertension.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sitagliptin phosphate: a DPP-4 inhibitor for the treatment of type 2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE): A Randomized Controlled Trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NPY1-36 and PYY1-36 activate cardiac fibroblasts: an effect enhanced by genetic hypertension and inhibition of dipeptidyl peptidase 4

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Left ventricular diastolic dysfunction and myocardial stiffness in diabetic mice is attenuated by inhibition of dipeptidyl peptidase 4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DPP-4 (CD26) inhibitor alogliptin inhibits atherosclerosis in diabetic apolipoprotein E-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sitagliptin protects rat kidneys from acute ischemia-reperfusion injury via upregulation of GLP-1 and GLP-1 receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of vildagliptin, a dipeptidyl peptidase 4 inhibitor, on cardiac hypertrophy induced by chronic beta-adrenergic stimulation in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trends in prevalence and outcome of heart failure with preserved ejection fraction

1 reference

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12 December 2020

based on heuristic

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Risk factors for heart failure are associated with alterations of the LV end-diastolic pressure-volume relationship in non-heart failure individuals: data from a large-scale, population-based cohort

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

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Filling Pressures and Collagen Metabolism in Hypertensive Patients With Heart Failure and Normal Ejection Fraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/27922176

12 December 2020

based on heuristic

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Identifiers

10.1111/BPH.13686

1 reference

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29 March 2020

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29 March 2020

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