Protein kinase G signaling in cardiac pathophysiology: Impact of proteomics on clinical trials (Q38670275)

5 September 2017

Protein kinase G signaling in cardiac pathophysiology: Impact of proteomics on clinical trials (English)

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5 September 2017

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26670943%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

Ronald J Holewinski

series ordinal

2

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9 June 2020

Erin L Crowgey

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26670943%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Jennifer E Van Eyk

series ordinal

4

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9 June 2020

publication date

16 December 2015

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5 September 2017

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9 June 2020

volume

16

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9 June 2020

issue

5

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9 June 2020

page(s)

894-905

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Heart Disease and Stroke Statistics--2015 Update: A Report From the American Heart Association

9 June 2020

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Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics

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Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

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Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial

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cGMP-binding prepares PKG for substrate binding by disclosing the C-terminal domain.

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Cysteine redox sensor in PKGIa enables oxidant-induced activation

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Prevention of PKG1α oxidation augments cardioprotection in the stressed heart.

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Functional cGMP-dependent protein kinase is phosphorylated in its catalytic domain at threonine-516.

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Activation of cGMP-dependent protein kinase by protein kinase C.

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A conserved serine juxtaposed to the pseudosubstrate site of type I cGMP-dependent protein kinase contributes strongly to autoinhibition and lower cGMP affinity

21 January 2018

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Cyclic GMP specifically suppresses Type-Ialpha cGMP-dependent protein kinase expression by ubiquitination

21 January 2018

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Catalytic activity of cGMP-dependent protein kinase type I in intact cells is independent of N-terminal autophosphorylation

21 January 2018

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Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns

21 January 2018

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N-terminal myristoylation is required for membrane localization of cGMP-dependent protein kinase type II.

21 January 2018

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Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes

21 January 2018

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Determination of cyclic nucleotide-dependent protein kinase substrate specificity by the use of peptide libraries on cellulose paper

21 January 2018

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A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

21 January 2018

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Abnormalities of calcium cycling in the hypertrophied and failing heart

21 January 2018

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Intracellular calcium release and cardiac disease

21 January 2018

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Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes

21 January 2018

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Protein kinase G phosphorylates Cav1.2 alpha1c and beta2 subunits

21 January 2018

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Phosphodiesterase 5A inhibition induces Na+/H+ exchanger blockade and protection against myocardial infarction.

21 January 2018

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Decreased activity of the Na+/H+ exchanger by phosphodiesterase 5A inhibition is attributed to an increase in protein phosphatase activity

21 January 2018

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Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure

21 January 2018

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TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling

21 January 2018

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Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition

21 January 2018

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Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition

21 January 2018

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Inhibition of Galphaq-dependent PLC-beta1 activity by PKG and PKA is mediated by phosphorylation of RGS4 and GRK2.

21 January 2018

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Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart

21 January 2018

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Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2.

21 January 2018

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The role of TGF-beta signaling in myocardial infarction and cardiac remodeling

21 January 2018

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus

21 January 2018

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TGF-beta signal transduction

21 January 2018

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Myocardial remodeling is controlled by myocyte-targeted gene regulation of phosphodiesterase type 5.

21 January 2018

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Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart

21 January 2018

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A novel interaction of cGMP-dependent protein kinase I with troponin T

21 January 2018

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Myofilament calcium regulation in human myocardium

21 January 2018

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Role of cyclic GMP-dependent protein kinase in the contractile response to exogenous nitric oxide in rat cardiac myocytes

21 January 2018

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PDE5A suppression of acute beta-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation

21 January 2018

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Myofilament Ca2+ desensitization mediates positive lusitropic effect of neuronal nitric oxide synthase in left ventricular myocytes from murine hypertensive heart.

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Gigantic business: titin properties and function through thick and thin

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Heart failure with preserved ejection fraction: mechanisms, clinical features, and therapies

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Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs.

21 January 2018

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Differential changes in titin domain phosphorylation increase myofilament stiffness in failing human hearts.

21 January 2018

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Protein kinase-A phosphorylates titin in human heart muscle and reduces myofibrillar passive tension

21 January 2018

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PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness

21 January 2018

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ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice.

21 January 2018

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Targeting GSK-3 family members in the heart: a very sharp double-edged sword

21 January 2018

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Inhibition of glycogen synthase kinase 3beta during heart failure is protective

21 January 2018

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Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β.

21 January 2018

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Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension

21 January 2018

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Mitigation of the progression of heart failure with sildenafil involves inhibition of RhoA/Rho-kinase pathway

21 January 2018

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Desmin modifications associate with amyloid-like oligomers deposition in heart failure

21 January 2018

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Protein kinase g positively regulates proteasome-mediated degradation of misfolded proteins.

21 January 2018

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Muscarinic 2 receptors modulate cardiac proteasome function in a protein kinase G-dependent manner

21 January 2018

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Proteotoxicity and cardiac dysfunction

21 January 2018

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Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure

21 January 2018

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The effects of phosphodiesterase-5 inhibition with sildenafil on pulmonary hemodynamics and diffusion capacity, exercise ventilatory efficiency, and oxygen uptake kinetics in chronic heart failure

21 January 2018

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Sildenafil and B-type natriuretic peptide acutely phosphorylate titin and improve diastolic distensibility in vivo

21 January 2018

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Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction.

21 January 2018

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Low myocardial protein kinase G activity in heart failure with preserved ejection fraction.

21 January 2018

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Sildenafil and exercise capacity in heart failure

21 January 2018

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Pressure-overload magnitude-dependence of the anti-hypertrophic efficacy of PDE5A inhibition

21 January 2018

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Nitric oxide synthases in heart failure

21 January 2018

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Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

21 January 2018

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Soluble guanylate cyclase: a potential therapeutic target for heart failure

21 January 2018

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21 January 2018

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Omega-3 fatty acids prevent pressure overload-induced cardiac fibrosis through activation of cyclic GMP/protein kinase G signaling in cardiac fibroblasts

21 January 2018

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Large-scale phosphorylation analysis of mouse liver

21 January 2018

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Highly selective enrichment of phosphorylated peptides from peptide mixtures using titanium dioxide microcolumns.

21 January 2018

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Global, in vivo, and site-specific phosphorylation dynamics in signaling networks

21 January 2018

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Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration.

21 January 2018

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Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3)

21 January 2018

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Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase

21 January 2018

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PDE5 inhibitor efficacy is estrogen dependent in female heart disease

21 January 2018

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Affinity purification-mass spectrometry. Powerful tools for the characterization of protein complexes

21 January 2018

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Evaluation of kinase inhibitor selectivity by chemical proteomics

21 January 2018

1 reference

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Investigating the dynamic nature of the interactions between nuclear proteins and histones upon DNA damage using an immobilized peptide chemical proteomics approach

21 January 2018

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Identification of novel target proteins of cyclic GMP signaling pathways using chemical proteomics

21 January 2018

1 reference

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Analysis of the cGMP/cAMP interactome using a chemical proteomics approach in mammalian heart tissue validates sphingosine kinase type 1-interacting protein as a genuine and highly abundant AKAP.

21 January 2018

1 reference

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A crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details of isoform-specific anchoring

21 January 2018

1 reference

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Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201500401

A travel guide to Cytoscape plugins

21 January 2018

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BiNGO: a Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201500401

Myocardial Titin Hypophosphorylation Importantly Contributes to Heart Failure With Preserved Ejection Fraction in a Rat Metabolic Risk Model

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201500401

Selective Isolation at the Femtomole Level of Phosphopeptides from Proteolytic Digests Using 2D-NanoLC-ESI-MS/MS and Titanium Oxide Precolumns

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1002/PMIC.201500401

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26670943%20AND%20SRC:MED&resulttype=core&format=json

release_d3tdnwtisbavhh4azkdug7rlt4

9 June 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/d3tdnwtisbavhh4azkdug7rlt4

mapped directly with Wikidata item

24 November 2022

based on heuristic

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