A tough row to hoe: when replication forks encounter DNA damage (Q90258518)

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12 April 2020

title

A tough row to hoe: when replication forks encounter DNA damage (English)

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12 April 2020

2

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12 April 2020

author name string

Darshil R Patel

series ordinal

1

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12 April 2020

publication date

4 December 2018

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Biochemical Society Transactions

12 April 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30514768%20AND%20SRC:MED&resulttype=core&format=json

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volume

46

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12 April 2020

issue

6

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page(s)

1643-1651

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Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress

12 April 2020

cites work

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12 December 2020

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

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12 December 2020

The DNA replication checkpoint response stabilizes stalled replication forks

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12 December 2020

Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects

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12 December 2020

CELLULAR DNA REPLICASES: Components and Dynamics at the Replication Fork

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12 December 2020

The effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of nonhomologous end-joining

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12 December 2020

ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks

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12 December 2020

Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells

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12 December 2020

Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1.

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12 December 2020

The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

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12 December 2020

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

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12 December 2020

The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities.

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12 December 2020

ATR: an essential regulator of genome integrity

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12 December 2020

Schimke immuno-osseous dysplasia: SMARCAL1 loss-of-function and phenotypic correlation.

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12 December 2020

ATR/Mec1: coordinating fork stability and repair.

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12 December 2020

Replication fork reversal and the maintenance of genome stability

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12 December 2020

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

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12 December 2020

The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks

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12 December 2020

The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart

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12 December 2020

Maintaining genome stability at the replication fork

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12 December 2020

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

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12 December 2020

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

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12 December 2020

Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

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12 December 2020

BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair

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12 December 2020

Homologous recombination and its regulation

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12 December 2020

The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing.

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12 December 2020

Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress

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12 December 2020

A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.

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12 December 2020

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

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12 December 2020

ATR phosphorylates SMARCAL1 to prevent replication fork collapse

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12 December 2020

Strand invasion by HLTF as a mechanism for template switch in fork rescue

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12 December 2020

The DNA translocase FANCM/MHF promotes replication traverse of DNA interstrand crosslinks

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12 December 2020

Mechanism and regulation of incisions during DNA interstrand cross-link repair

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12 December 2020

FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51

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12 December 2020

Replication fork reversal in eukaryotes: from dead end to dynamic response

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12 December 2020

DNA2 drives processing and restart of reversed replication forks in human cells.

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12 December 2020

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

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12 December 2020

Resistance to therapy in BRCA2 mutant cells due to loss of the nucleosome remodeling factor CHD4.

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12 December 2020

Genome Protection by the 9-1-1 Complex Subunit HUS1 Requires Clamp Formation, DNA Contacts, and ATR Signaling-independent Effector Functions

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12 December 2020

HUS1 regulates in vivo responses to genotoxic chemotherapies

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12 December 2020

BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks

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12 December 2020

A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination

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12 December 2020

High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation

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12 December 2020

Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart

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12 December 2020

The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability.

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12 December 2020

Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathway

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12 December 2020

The Fanconi anaemia pathway: new players and new functions

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12 December 2020

FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair

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12 December 2020

Replication fork stability confers chemoresistance in BRCA-deficient cells

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12 December 2020

Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.

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12 December 2020

The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress.

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12 December 2020

Combining electron microscopy with single molecule DNA fiber approaches to study DNA replication dynamics

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12 December 2020

ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells.

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12 December 2020

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

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12 December 2020

Regulation of DNA damage tolerance in mammalian cells by post-translational modifications of PCNA.

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12 December 2020

RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks.

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12 December 2020

Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments

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12 December 2020

Abro1 maintains genome stability and limits replication stress by protecting replication fork stability

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12 December 2020

BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination.

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12 December 2020

BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites.

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12 December 2020

Functions of SMARCAL1, ZRANB3, and HLTF in maintaining genome stability

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12 December 2020

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.

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12 December 2020

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

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12 December 2020

Replication fork reversal triggers fork degradation in BRCA2-defective cells

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12 December 2020

Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.

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12 December 2020

53BP1 and BRCA1 control pathway choice for stalled replication restart

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12 December 2020

Nucleases Acting at Stalled Forks: How to Reboot the Replication Program with a Few Shortcuts

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12 December 2020

Replication Fork Reversal: Players and Guardians.

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12 December 2020

SAMHD1 acts at stalled replication forks to prevent interferon induction

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12 December 2020

RADX Modulates RAD51 Activity to Control Replication Fork Protection

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12 December 2020

Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase

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12 December 2020

ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links

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12 December 2020

The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection

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12 December 2020

Identifiers

DOI

10.1042/BST20180308

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12 April 2020

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12 April 2020

PubMed publication ID

30514768

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