Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors (Q92733484)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31197141%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

title

Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors (English)

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1 May 2020

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5

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John L Collar

6

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1 May 2020

Yanhong Shi

8

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Aimin Liu

9

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1 May 2020

Bruce E Herring

11

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1 May 2020

author name string

Wei Zhang

1

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1 May 2020

Si-Lu Yang

2

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1 May 2020

Mei Yang

3

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1 May 2020

Stephanie Herrlinger

4

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1 May 2020

Edgar Fierro

7

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1 May 2020

Hui Lu

10

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1 May 2020

Ming-Lei Guo

12

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1 May 2020

Shilpa Buch

13

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1 May 2020

Zhen Zhao

14

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1 May 2020

Jian Xu

15

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Zhipeng Lu

16

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1 May 2020

Jian-Fu Chen

17

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language of work or name

English

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publication date

13 June 2019

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1 May 2020

published in

Nature Communications

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volume

10

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1 May 2020

issue

1

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1 May 2020

page(s)

2612

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Ciliogenesis and cell cycle alterations contribute to KIF2A-related malformations of cortical development.

1 May 2020

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PLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation

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Glial-Specific Functions of Microcephaly Protein WDR62 and Interaction with the Mitotic Kinase AURKA Are Essential for Drosophila Brain Growth.

11 February 2021

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Cell diversity and network dynamics in photosensitive human brain organoids.

11 February 2021

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Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly

11 February 2021

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Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia

11 February 2021

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Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate

11 February 2021

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Cilium assembly and disassembly

11 February 2021

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Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

11 February 2021

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CPAP promotes timely cilium disassembly to maintain neural progenitor pool

11 February 2021

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The primary cilium as a cellular receiver: organizing ciliary GPCR signaling

11 February 2021

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The Microcephaly-Associated Protein Wdr62/CG7337 Is Required to Maintain Centrosome Asymmetry in Drosophila Neuroblasts

11 February 2021

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Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication

11 February 2021

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The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation.

11 February 2021

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Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size

11 February 2021

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Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

11 February 2021

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Genome engineering using the CRISPR-Cas9 system

11 February 2021

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Cerebral organoids model human brain development and microcephaly

11 February 2021

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Microtubule-depolymerizing kinesins

11 February 2021

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Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly

11 February 2021

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A genomic toolkit to investigate kinesin and myosin motor function in cells

11 February 2021

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MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway

11 February 2021

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Cdk5rap2 exposes the centrosomal root of microcephaly syndromes

11 February 2021

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11 February 2021

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A new subtype of progenitor cell in the mouse embryonic neocortex

11 February 2021

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Do cilia put brakes on the cell cycle?

11 February 2021

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Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors

11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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WDR62 is associated with the spindle pole and is mutated in human microcephaly

11 February 2021

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Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture

11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling

11 February 2021

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11 February 2021

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Neurogenic radial glia in the outer subventricular zone of human neocortex

11 February 2021

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11 February 2021

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Primary microcephaly: do all roads lead to Rome?

11 February 2021

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Cdk4/cyclinD1 overexpression in neural stem cells shortens G1, delays neurogenesis, and promotes the generation and expansion of basal progenitors.

11 February 2021

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Cep164, a novel centriole appendage protein required for primary cilium formation

11 February 2021

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The primary cilium as the cell's antenna: signaling at a sensory organelle

11 February 2021

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Molecular genetic determinants of human brain size

11 February 2021

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G1 phase regulation, area-specific cell cycle control, and cytoarchitectonics in the primate cortex

11 February 2021

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Characterization of the intraflagellar transport complex B core: direct interaction of the IFT81 and IFT74/72 subunits

11 February 2021

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Evolution of the brain and intelligence

11 February 2021

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The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles

11 February 2021

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Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella

11 February 2021

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10.1038/S41467-019-10497-2

11 February 2021

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31197141%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

0 references

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1 May 2020

PubMed publication ID

31197141

1 reference