Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy (Q93043721)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31474370%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

title

Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31474370%20AND%20SRC:MED&resulttype=core&format=json

single cell transcriptomics

3 May 2020

main subject

1 reference

A curated database reveals trends in single-cell transcriptomics

7 February 2021

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31474370%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Guray Akturk

24

1 reference

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3 May 2020

0 references

31

Ephraim Kenigsberg

1 reference

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3 May 2020

29

Miriam Merad

1 reference

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3 May 2020

27

Sacha Gnjatic

1 reference

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3 May 2020

25

Eric E Schadt

1 reference

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3 May 2020

17

Subra Kugathasan

1 reference

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3 May 2020

30

Judy H Cho

1 reference

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3 May 2020

7

Kyle Gettler

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31474370%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

author name string

Jerome C Martin

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31474370%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Christie Chang

2

1 reference

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3 May 2020

Ryan Ungaro

4

1 reference

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3 May 2020

Mamta Giri

5

1 reference

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3 May 2020

John A Grout

6

1 reference

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3 May 2020

Ling-Shiang Chuang

8

1 reference

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3 May 2020

Shikha Nayar

9

1 reference

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3 May 2020

Alexander J Greenstein

10

1 reference

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3 May 2020

Marla Dubinsky

11

1 reference

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3 May 2020

Laura Walker

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31474370%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Andrew Leader

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31474370%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Jay S Fine

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31474370%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Charles E Whitehurst

15

1 reference

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3 May 2020

M Lamine Mbow

16

1 reference

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3 May 2020

Lee A Denson

18

1 reference

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3 May 2020

Jeffrey S Hyams

19

1 reference

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3 May 2020

Joshua R Friedman

20

1 reference

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3 May 2020

Prerak T Desai

21

1 reference

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3 May 2020

Huaibin M Ko

22

1 reference

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3 May 2020

Ilaria Laface

23

1 reference

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3 May 2020

Helene Salmon

26

1 reference

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3 May 2020

Adeeb H Rahman

28

1 reference

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3 May 2020

publication date

29 August 2019

1 reference

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external data available at URL

3 May 2020

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE134809

1 reference

A curated database reveals trends in single-cell transcriptomics

7 February 2021

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31474370%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

volume

178

1 reference

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3 May 2020

issue

6

1 reference

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3 May 2020

page(s)

1493-1508.e20

1 reference

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describes a project that uses

3 May 2020

blood

1 reference

A curated database reveals trends in single-cell transcriptomics

7 February 2021

small intestine

1 reference

A curated database reveals trends in single-cell transcriptomics

7 February 2021

ileum

1 reference

A curated database reveals trends in single-cell transcriptomics

7 February 2021

10x Genomics Chromium

1 reference

A curated database reveals trends in single-cell transcriptomics

7 February 2021

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7060942/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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11 February 2021

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Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.

11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency.

11 February 2021

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11 February 2021

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11 February 2021

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Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases

11 February 2021

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11 February 2021

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Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species

11 February 2021

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11 February 2021

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11 February 2021

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Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity

11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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Cytokines in inflammatory bowel disease

11 February 2021

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Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses

11 February 2021

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11 February 2021

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11 February 2021

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Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids.

11 February 2021

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The who's who of T-cell differentiation: human memory T-cell subsets

11 February 2021

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CD14(hi)HLA-DR(dim) macrophages, with a resemblance to classical blood monocytes, dominate inflamed mucosa in Crohn's disease.

11 February 2021

1 reference

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Galectin 1 modulates plasma cell homeostasis and regulates the humoral immune response

11 February 2021

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The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting

11 February 2021

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Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

11 February 2021

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Innate lymphoid cells--how did we miss them?

11 February 2021

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Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

11 February 2021

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Ustekinumab induction and maintenance therapy in refractory Crohn's disease

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

Mucosal CXCR4+ IgG plasma cells contribute to the pathogenesis of human ulcerative colitis through FcγR-mediated CD14 macrophage activation.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

Fiji: an open-source platform for biological-image analysis

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

TrakEM2 software for neural circuit reconstruction

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

Development of the Crohn's disease digestive damage score, the Lémann score

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

Inflammation anergy in human intestinal macrophages is due to Smad-induced IkappaBalpha expression and NF-kappaB inactivation

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

Inflammatory bowel disease

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

Gut-associated lymphoid tissue contains the molecular machinery to support T-cell-dependent and T-cell-independent class switch recombination.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

Galectin-1 promotes immunoglobulin production during plasma cell differentiation

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

CCR7 and its ligands: balancing immunity and tolerance

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

TREM-1--expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

Phenotypic heterogeneity of the endothelium: II. Representative vascular beds

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

Role of fecal calprotectin as a biomarker of intestinal inflammation in inflammatory bowel disease

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

A live-cell assay to detect antigen-specific CD4+ T cells with diverse cytokine profiles

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

Impaired IgA class switching in APRIL-deficient mice

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

Regulation of IL-11 expression in intestinal myofibroblasts: role of c-Jun AP-1- and MAPK-dependent pathways

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

Transcriptional analysis of the B cell germinal center reaction

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

Interleukin-1beta and tumor necrosis factor-alpha induce chemokine and matrix metalloproteinase gene expression in human colonic subepithelial myofibroblasts

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7060942

10.1016/J.CELL.2019.08.008

11 February 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31474370%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31474370%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

PubMed publication ID

31474370

1 reference