Integrated single-cell and bulk gene expression and ATAC-seq reveals heterogeneity and early changes in pathways associated with resistance to cetuximab in HNSCC-sensitive cell lines (Q94501486)

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scientific article published on 04 May 2020

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English	Integrated single-cell and bulk gene expression and ATAC-seq reveals heterogeneity and early changes in pathways associated with resistance to cetuximab in HNSCC-sensitive cell lines	scientific article published on 04 May 2020

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15 May 2020

Integrated single-cell and bulk gene expression and ATAC-seq reveals heterogeneity and early changes in pathways associated with resistance to cetuximab in HNSCC-sensitive cell lines (English)

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15 May 2020

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Elana J. Fertig

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Elana J Fertig

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15 May 2020

Srinivasan Yegnasubramanian

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Srinivasan Yegnasubramanian

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15 May 2020

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Luciane T Kagohara

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15 May 2020

Fernando Zamuner

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15 May 2020

Emily F Davis-Marcisak

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15 May 2020

Gaurav Sharma

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15 May 2020

Michael Considine

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15 May 2020

Jawara Allen

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Daria A Gaykalova

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publication date

4 May 2020

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15 May 2020

British Journal of Cancer

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15 May 2020

describes a project that uses

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tximport

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CZ Software Mentions: A large dataset of software mentions in the biomedical literature

Targeted cancer therapy

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Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab

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Cetuximab: from bench to bedside.

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Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival

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CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network

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Cetuximab promotes epithelial to mesenchymal transition and cancer associated fibroblasts in patients with head and neck cancer

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TRANSFAC: transcriptional regulation, from patterns to profiles

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TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes

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7 January 2021

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Decreased SMAD4 expression is associated with induction of epithelial-to-mesenchymal transition and cetuximab resistance in head and neck squamous cell carcinoma

1 reference

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EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

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Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells.

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BET inhibition overcomes receptor tyrosine kinase-mediated cetuximab resistance in HNSCC.

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Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs

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Learning dysregulated pathways in cancers from differential variability analysis

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Recovering Gene Interactions from Single-Cell Data Using Data Diffusion

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Near-optimal probabilistic RNA-seq quantification

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Salmon provides fast and bias-aware quantification of transcript expression

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Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

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Fast gapped-read alignment with Bowtie 2

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The Sequence Alignment/Map format and SAMtools

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Model-based analysis of ChIP-Seq (MACS)

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Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

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Efficacy of gemcitabine and cetuximab combination treatment in head and neck squamous cell carcinoma

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Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data

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The Molecular Signatures Database (MSigDB) hallmark gene set collection

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RNA velocity of single cells

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An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance

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EGFR inhibition promotes an aggressive invasion pattern mediated by mesenchymal-like tumor cells within squamous cell carcinomas

1 reference

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7 January 2021

based on heuristic

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AXL mediates resistance to cetuximab therapy

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7 January 2021

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Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance.

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Poised epigenetic states and acquired drug resistance in cancer

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AP-2alpha induces epigenetic silencing of tumor suppressive genes and microsatellite instability in head and neck squamous cell carcinoma

1 reference

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Aberrant expressions of AP-2α splice variants in pancreatic cancer

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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7 January 2021

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Identifiers

10.1038/S41416-020-0851-5

1 reference

Europe PubMed Central

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15 May 2020

1 reference

Europe PubMed Central

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15 May 2020

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