Personalization of the immunosuppressive treatment in renal transplant recipients: the great challenge in "omics" medicine (Q28082746)

chronic renal insufficiency

main subject

3 references

13 March 2019

1 July 2019

25 June 2019

immunosuppressive drug

1 reference

26 October 2020

kidney transplantation

1 reference

24 January 2021

1 reference

Simona Granata

2

0 references

Gianluigi Zaza

object named as

Gianluigi Zaza

1

0 references

author name string

Paola Tomei

3

1 reference

Alessandra Gassa

4

1 reference

Antonio Lupo

5

1 reference

International Journal of Molecular Sciences

language of work or name

1 reference

17 February 2015

6 references

13 March 2019

1 July 2019

25 June 2019

26 October 2020

24 January 2021

7 references

13 March 2019

1 July 2019

25 June 2019

29 May 2020

26 October 2020

24 January 2021

16

1 reference

page(s)

4281-305

1 reference

issue

2

1 reference

Creative Commons Attribution

copyright license

5 references

13 March 2019

1 July 2019

25 June 2019

26 October 2020

24 January 2021

0 references

on focus list of Wikimedia project

ScienceSource

0 references

cites work

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Associations of ABCB1 and IL-10 genetic polymorphisms with sirolimus-induced dyslipidemia in renal transplant recipients

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Associations of ABCB1 3435C>T and IL-10-1082G>A polymorphisms with long-term sirolimus dose requirements in renal transplant patients

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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The prevalence of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T and its influence on mycophenolic acid pharmacokinetics in stable renal transplant patients.

29 September 2017

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29 September 2017

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UGT1A9 -275T>A/-2152C>T polymorphisms correlate with low MPA exposure and acute rejection in MMF/tacrolimus-treated kidney transplant patients

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Inheritance and drug response

29 September 2017

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Humoral rejection in kidney transplantation: new concepts in diagnosis and treatment

29 September 2017

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29 September 2017

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29 September 2017

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Chronic humoral rejection: identification of antibody-mediated chronic renal allograft rejection by C4d deposits in peritubular capillaries

29 September 2017

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Long-term results of TPMT activity monitoring in azathioprine-treated renal allograft recipients

29 September 2017

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29 September 2017

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Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia

29 September 2017

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Pharmacokinetics of mycophenolic acid in renal insufficiency

29 September 2017

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CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity

29 September 2017

1 reference

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Thiopurine methyltransferase activity and its relationship to the occurrence of rejection episodes in paediatric renal transplant recipients treated with azathioprine

29 September 2017

1 reference

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Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus

29 September 2017

1 reference

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Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine

29 September 2017

1 reference

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29 September 2017

1 reference

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The design and development of an immunosuppressive drug, mycophenolate mofetil

29 September 2017

1 reference

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The clinical pharmacology of 6-mercaptopurine

29 September 2017

1 reference

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In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism

29 September 2017

1 reference

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Effect of CYP3A4*22, POR*28, and PPARA rs4253728 on sirolimus in vitro metabolism and trough concentrations in kidney transplant recipients.

29 September 2017

1 reference

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Changes in quality of life after renal transplantation.

2 June 2018

1 reference

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The role of DNA mismatch repair in drug resistance.

2 June 2018

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Early metabolic changes in peripheral blood cells of renal transplant recipients treated with cyclosporine A.

2 June 2018

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Control of antidonor antibody production with tacrolimus and mycophenolate mofetil in renal allograft recipients with chronic rejection

21 January 2018

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21 January 2018

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Tacrolimus pharmacogenetics: polymorphisms associated with expression of cytochrome p4503A5 and P-glycoprotein correlate with dose requirement

21 January 2018

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Impact of cytochrome p450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients.

21 January 2018

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The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients

21 January 2018

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A pharmacogenetic strategy for immunosuppression based on the CYP3A5 genotype.

21 January 2018

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A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients.

21 January 2018

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Influence of CYP3A5 and MDR1 (ABCB1) polymorphisms on the pharmacokinetics of tacrolimus in renal transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

Impact of CYP3A5 and MDR1(ABCB1) C3435T polymorphisms on the pharmacokinetics of tacrolimus in renal transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

Influence of CYP3A5 and MDR1 polymorphisms on tacrolimus concentration in the early stage after renal transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

The influence of genetic polymorphisms of cytochrome P450 3A5 and ABCB1 on starting dose- and weight-standardized tacrolimus trough concentrations after kidney transplantation in relation to renal function.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

Do drug transporter (ABCB1) SNPs and P-glycoprotein function influence cyclosporine and macrolides exposure in renal transplant patients? Results of the pharmacogenomic substudy within the symphony study

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

Influence of ABCB1 genetic polymorphisms on cyclosporine intracellular concentration in transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

ABCB1 genotype of the donor but not of the recipient is a major risk factor for cyclosporine-related nephrotoxicity after renal transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

Calcineurin inhibitor-induced nephrotoxicity and renal expression of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

Donor age and ABCB1 1199G>A genetic polymorphism are independent factors affecting long-term renal function after kidney transplantation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

Pharmacokinetics of mycophenolic acid and its phenolic-glucuronide and ACYl glucuronide metabolites in stable thoracic transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

The impact of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T on early mycophenolic acid dose-interval exposure in de novo renal allograft recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

C-440T/T-331C polymorphisms in the UGT1A9 gene affect the pharmacokinetics of mycophenolic acid in kidney transplantation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

Mycophenolic acid-related diarrhea is not associated with polymorphisms in SLCO1B nor with ABCB1 in renal transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

Pre-transplant inosine monophosphate dehydrogenase activity is associated with clinical outcome after renal transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

Correlation of IMPDH1 gene polymorphisms with subclinical acute rejection and mycophenolic acid exposure parameters on day 28 after renal transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

Consequences of genetic polymorphisms for sirolimus requirements after renal transplant in patients on primary sirolimus therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

CYP3A5*3 influences sirolimus oral clearance in de novo and stable renal transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

Sirolimus and tacrolimus trough concentrations and dose requirements after kidney transplantation in relation to CYP3A5 and MDR1 polymorphisms and steroids

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

Practical FDR-based sample size calculations in microarray experiments.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

CYP3A5 and ABCB1 Polymorphisms and Tacrolimus Pharmacokinetics in Renal Transplant Candidates: Guidelines from an Experimental Study

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

The Cost-Effectiveness of a Pharmacogenetic Test: A Trial-Based Evaluation of TPMT Genotyping for Azathioprine

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024281

Optimization of initial tacrolimus dose using pharmacogenetic testing

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346957

AcylMPAG plasma concentrations and mycophenolic acid-related side effects in patients undergoing renal transplantation are not related to the UGT2B7-840G>A gene polymorphism.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346957

The impact of thiopurine S-methyltransferase polymorphisms on azathioprine dose 1 year after renal transplantation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346957

Acute humoral rejection in kidney transplantation: II. Morphology, immunopathology, and pathologic classification.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346957

The need for education in pharmacogenomics: a regulatory perspective

27 November 2018

1 reference

12 December 2020

Analysis of independent microarray datasets of renal biopsies identifies a robust transcript signature of acute allograft rejection

1 reference

12 December 2020

Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene

1 reference

12 December 2020

Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine-sirolimus interaction

1 reference

12 December 2020

Cost-effectiveness studies of renal transplantation

1 reference

12 December 2020

Declining intracellular T-lymphocyte concentration of cyclosporine a precedes acute rejection in kidney transplant recipients

1 reference

12 December 2020

Pharmacogenetics of irinotecan: clinical perspectives on the utility of genotyping

1 reference

12 December 2020

Polymorphisms in CYP3A5, CYP3A4, and ABCB1 are not associated with cyclosporine pharmacokinetics nor with cyclosporine clinical end points after renal transplantation

1 reference

12 December 2020

Some mutations of exon-7 in cytochrome P450 gene 3A4 and their effect on 6beta-hydroxylation of cortisol

1 reference

12 December 2020

Impact of renal cadaveric transplantation on survival in end-stage renal failure: evidence for reduced mortality risk compared with hemodialysis during long-term follow-up

1 reference

12 December 2020

Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: a contribution of humoral immunity to chronic allograft rejection

1 reference

12 December 2020

Thiopurine methyltransferase genotype and the toxicity of azathioprine in Japanese

1 reference

12 December 2020

Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat

1 reference

12 December 2020

CYP3A5 and CYP3A4 but not MDR1 single-nucleotide polymorphisms determine long-term tacrolimus disposition and drug-related nephrotoxicity in renal recipients

1 reference

12 December 2020

The Impact of UGT1A8, UGT1A9, and UGT2B7 Genetic Polymorphisms on the Pharmacokinetic Profile of Mycophenolic Acid After a Single Oral Dose in Healthy Volunteers

1 reference

12 December 2020

Thiopurine S-methyltransferase: a genetic polymorphism that affects a small number of drugs in a big way

1 reference

12 December 2020

Cyp3A4, Cyp3A5, and MDR-1 genetic influences on tacrolimus pharmacokinetics in renal transplant recipients

1 reference

12 December 2020

Inosine monophosphate dehydrogenase polymorphisms and renal allograft outcome

1 reference

12 December 2020

6-thiopurines as substrates and inhibitors of purine oxidases: a pathway for conversion of azathioprine into 6-thiouric acid without release of 6-mercaptopurine

1 reference

12 December 2020

CYP3A5 genotype markedly influences the pharmacokinetics of tacrolimus and sirolimus in kidney transplant recipients

1 reference

12 December 2020

Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture

1 reference

12 December 2020

Pharmacogenetics of tacrolimus after renal transplantation: analysis of polymorphisms in genes encoding 16 drug metabolizing enzymes

1 reference

12 December 2020

Complement activation in acute humoral renal allograft rejection: diagnostic significance of C4d deposits in peritubular capillaries

1 reference

12 December 2020

Gene-expression profiles and age of donor kidney biopsies obtained before transplantation distinguish medium term graft function

1 reference

12 December 2020

Identifiers

DOI

10.3390/IJMS16024281

1 reference

634355

634355

1 reference

1 reference

1 reference