Nicastrin (Q14911609)

http://www.ebi.ac.uk/interpro/protein/P57716

group translocator

1 reference

Transporter Classification Database ID

4.G.1.1.1

hierarchical database ID heuristic

2 October 2019

based on heuristic

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

25 May 2022

1 reference

25 May 2022

endopeptidase activity

1 reference

16 July 2018

Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities

http://www.ebi.ac.uk/QuickGO/annotations?protein=P57716&geneProductId=UniProtKB:P57716

protein binding

5 references

14 February 2019

Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

ER-stress-inducible Herp, facilitates the degradation of immature nicastrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

endopeptidase activity

endopeptidase activity

Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

cell component

melanosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

1 reference

14 February 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P57716&geneProductId=UniProtKB:P57716

3 references

10 September 2018

TAS

10 September 2018

Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain

http://www.ebi.ac.uk/QuickGO/annotations?protein=P57716&geneProductId=UniProtKB:P57716

10 September 2018

Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled alpha-subunits

http://www.ebi.ac.uk/QuickGO/annotations?protein=P57716&geneProductId=UniProtKB:P57716

Golgi apparatus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled alpha-subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

integral component of plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

cytoplasmic vesicle membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

1 reference

14 February 2019

cytoplasmic vesicle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

1 reference

14 February 2019

integral component of membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

gamma-secretase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

4 references

14 February 2019

14 February 2019

Spatial segregation of gamma-secretase and substrates in distinct membrane domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

integral component of presynaptic membrane

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P57716&geneProductId=UniProtKB:P57716

lysosome

1 reference

14 February 2019

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

6 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

Cellular localization of Nicastrin affects amyloid beta species production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled alpha-subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

synaptic vesicle

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

Pre-synaptic localization of the γ-secretase-inhibiting protein p24α2 in the mammalian brain.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

protein-containing complex

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

biological process

T cell proliferation

1 reference

14 February 2019

Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

myeloid cell homeostasis

1 reference

14 February 2019

Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

positive regulation of catalytic activity

epithelial cell proliferation

IGI

membrane protein ectodomain proteolysis

amyloid-beta metabolic process

1 reference

14 February 2019

Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

protein processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

amyloid-beta formation

amyloid precursor protein metabolic process

3 references

Notch signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

1 reference

14 February 2019

Notch receptor processing

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

cerebellum development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

dopamine receptor signaling pathway

1 reference

14 February 2019

Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

glutamate receptor signaling pathway

1 reference

14 February 2019

Synaptic function of nicastrin in hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

learning or memory

1 reference

14 February 2019

Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

central nervous system myelination

1 reference

14 February 2019

Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

adult behavior

1 reference

14 February 2019

Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

amyloid precursor protein metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

amyloid precursor protein biosynthetic process

1 reference

14 February 2019

Cellular localization of Nicastrin affects amyloid beta species production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

positive regulation of amyloid precursor protein biosynthetic process

1 reference

14 February 2019

Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

neuron apoptotic process

1 reference

14 February 2019

Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

neuron death

1 reference

14 February 2019

Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

cellular response to calcium ion

1 reference

14 February 2019

Synaptic function of nicastrin in hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

regulation of long-term synaptic potentiation

1 reference

14 February 2019

Synaptic function of nicastrin in hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

short-term synaptic potentiation

1 reference

14 February 2019

Synaptic function of nicastrin in hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57716

Transporter Classification Database ID

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

4.G.1.1.1

2 references

Transporter Classification database

13 March 2020

Transporter Classification database