APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development (Q28592373)

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7 January 2020

title

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development (English)

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15634781%20AND%20SRC:MED&resulttype=core&format=json

Aph1 homolog C, gamma secretase subunit

7 January 2020

main subject

1 reference

Nicastrin

1 reference

Aph1 homolog B, gamma secretase subunit

1 reference

Presenilin 1

1 reference

Aph1 homolog A, gamma secretase subunit

1 reference

author name string

Guojun Ma

1

2 references

31 January 2017

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7 January 2020

Tong Li

2

2 references

31 January 2017

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7 January 2020

Donald L Price

3

1 reference

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7 January 2020

Philip C Wong

4

1 reference

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7 January 2020

language of work or name

English

0 references

publication date

1 January 2005

1 reference

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7 January 2020

published in

Journal of Neuroscience

2 references

31 January 2017

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7 January 2020

volume

25

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7 January 2020

page(s)

192-198

1 reference

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7 January 2020

issue

1

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31 January 2017

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Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

7 January 2020

cites work

1 reference

12 December 2020

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

12 December 2020

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

1 reference

12 December 2020

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

12 December 2020

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

12 December 2020

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

12 December 2020

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

1 reference

12 December 2020

Genetically engineered mouse models of neurodegenerative diseases

1 reference

12 December 2020

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

12 December 2020

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

1 reference

12 December 2020

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

1 reference

12 December 2020

The role of presenilin cofactors in the gamma-secretase complex

1 reference

12 December 2020

Reconstitution of gamma-secretase activity

1 reference

12 December 2020

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

12 December 2020

Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain

1 reference

12 December 2020

Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

1 reference

12 December 2020

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

1 reference

12 December 2020

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

12 December 2020

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

1 reference

12 December 2020

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

1 reference

12 December 2020

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

1 reference

12 December 2020

Mild cognitive impairment clinical trials

1 reference

12 December 2020

The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex

1 reference

12 December 2020

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

1 reference

12 December 2020

Membrane Topology and Nicastrin-enhanced Endoproteolysis of APH-1, a Component of the γ-Secretase Complex

1 reference

12 December 2020

A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex

1 reference

12 December 2020

The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities

1 reference

12 December 2020

Identification of distinct gamma-secretase complexes with different APH-1 variants

1 reference

12 December 2020

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

1 reference

12 December 2020

Intramembrane proteolysis: theme and variations.

1 reference

12 December 2020

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

1 reference

12 December 2020

Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form

1 reference

12 December 2020

Notch1 is required for the coordinate segmentation of somites

1 reference

12 December 2020

Notch1 is essential for postimplantation development in mice.

1 reference

12 December 2020

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

12 December 2020

Mutant genes in familial Alzheimer's disease and transgenic models

1 reference

12 December 2020

10.1523/JNEUROSCI.3814-04.2005

Identifiers

DOI

2 references

31 January 2017

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7 January 2020

1 reference

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7 January 2020

2 references

31 January 2017