Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain (Q28589919)

31 January 2017

title

Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain (English)

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31 January 2017

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Nicastrin

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Presenilin 1

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Golgi autoantigen, golgin subfamily a, 2

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Heat shock protein 5

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Calnexin

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Neurotrophic tyrosine kinase, receptor, type 2

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Peter Henry St George-Hyslop

author

16

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David Westaway

12

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Nobuo Sanjo

object named as

Nobuo Sanjo

3

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author name string

Fusheng Chen

1

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31 January 2017

Anurag Tandon

2

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31 January 2017

Yong-Jun Gu

4

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31 January 2017

Hiroshi Hasegawa

5

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31 January 2017

Shigeki Arawaka

6

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31 January 2017

Frank J. S. Lee

7

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31 January 2017

Xueying Ruan

8

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31 January 2017

Peter Mastrangelo

9

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31 January 2017

Serap Erdebil

10

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31 January 2017

Linda Wang

11

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31 January 2017

Howard T. J. Mount

13

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31 January 2017

Bruce Yankner

14

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31 January 2017

Paul E. Fraser

15

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31 January 2017

language of work or name

English

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publication date

30 May 2003

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Journal of Biological Chemistry

31 January 2017

published in

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31 January 2017

volume

278

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31 January 2017

issue

22

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31 January 2017

page(s)

19974–19979

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

31 January 2017

cites work

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

1 reference

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210049200

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210049200

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

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Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210049200

Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210049200

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210049200

Nicastrin binds to membrane-tethered Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210049200

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210049200

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210049200

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210049200

Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype

21 January 2018

1 reference

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Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210049200

The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein

21 January 2018

1 reference

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APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210049200

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

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A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

21 January 2018

1 reference

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Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210049200

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210049200

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210049200

Drosophila nicastrin is essential for the intramembranous cleavage of notch

21 January 2018

1 reference

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Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210049200

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210049200

Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210049200

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210049200

21 January 2018

Identifiers

DOI

10.1074/JBC.M210049200

1 reference

31 January 2017

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