The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling (Q24310890)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0035867

insulin like growth factor 1 receptor

1 reference

integrin subunit alpha V

1 reference

Insulin like growth factor 1

1 reference

Integrin subunit beta 3

1 reference

1 reference

Yoshikazu Takada

8

Yoshikazu

Takada

1 reference

19 October 2023

Jun Saegusa

1

Jun

Saegusa

1 reference

19 October 2023

Satoshi Yamaji

2

Satoshi

Yamaji

1 reference

19 October 2023

Katsuaki Ieguchi

3

Katsuaki

Ieguchi

1 reference

19 October 2023

Chun-Yi Wu

4

Chun-Yi

Wu

1 reference

19 October 2023

Kit S Lam

5

Kit S

Lam

1 reference

19 October 2023

Fu-Tong Liu

6

Fu-Tong

Liu

1 reference

19 October 2023

Yoko K Takada

7

Yoko K

Journal of Biological Chemistry

Takada

1 reference

19 October 2023

language of work or name

English

0 references

publication date

4 September 2009

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published in

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volume

284

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issue

36

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page(s)

24106-14

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cites work

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Crystal structure of the extracellular segment of integrin alpha Vbeta3

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Role of the integrin alphaVbeta3 in mediating increased smooth muscle cell responsiveness to IGF-I in response to hyperglycemic stress

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Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant

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The mucin Muc4 potentiates neuregulin signaling by increasing the cell-surface populations of ErbB2 and ErbB3.

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Interaction between insulin-like growth factor-I receptor and alphaVbeta3 integrin linked signaling pathways: cellular responses to changes in multiple signaling inputs

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Blocking ligand occupancy of the alphaVbeta3 integrin inhibits insulin-like growth factor I signaling in vascular smooth muscle cells

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Cell migration: interactions among integrins, IGFs and IGFBPs

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Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner

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Arg-Gly-Asp constrained within cyclic pentapeptides. Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1.

30 May 2018

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Integrins and their accessory adhesion molecules in mammary carcinomas: loss of polarization in poorly differentiated tumors

30 May 2018

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Increased risk of ovarian cancer in integrin beta3 Leu33Pro homozygotes

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Insulin-like growth factor-I signaling in smooth muscle cells is regulated by ligand binding to the 177CYDMKTTC184 sequence of the beta3-subunit of alphaVbeta3.

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Changing Ligand Specificities of αvβ1 and αvβ3 Integrins by Swapping a Short Diverse Sequence of the β Subunit

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Role of alphavbeta3 integrin receptors in breast tumor.

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29 November 2018

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Integrin alpha(v)beta(3) expression in colon carcinoma correlates with survival

29 November 2018

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12 December 2020

The C region of human insulin-like growth factor (IGF) I is required for high affinity binding to the type 1 IGF receptor.

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12 December 2020

Differential expression of integrin cell-substratum adhesion receptors on endothelium

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12 December 2020

Integrin alpha V beta 3 expression by bone-residing breast cancer metastases

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12 December 2020