Discs large MAGUK scaffold protein 1 (Q21113813)

L27 domain superfamily

1 reference

PDZ superfamily

1 reference

P-loop containing nucleoside triphosphate hydrolase

1 reference

Disks large 1-like

1 reference

auxiliary protein involved in transmembrane transport

1 reference

Transporter Classification Database ID

8.A.24.1.7

2 October 2019

hierarchical database ID heuristic

L27 domain, protein family

1 reference

Guanylate kinase-like domain, protein family

1 reference

PDZ-associated domain of NMDA receptors, protein family

1 reference

Disks large homologue 1, N-terminal PEST domain, protein family

1 reference

PDZ domain, protein family

1 reference

L27-1, protein family

1 reference

SH3 domain, protein family

1 reference

Guanylate kinase/L-type calcium channel beta subunit, protein family

1 reference

Guanylate kinase, conserved site, protein family

1 reference

1 reference

5 December 2018

1 reference

5 December 2018

1 reference

8 April 2019

Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

phosphoprotein phosphatase activity

1 reference

8 April 2019

Large-scale characterization of HeLa cell nuclear phosphoproteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

transmembrane transporter binding

1 reference

8 April 2019

Different isoforms of synapse-associated protein, SAP97, are expressed in the heart and have distinct effects on the voltage-gated K+ channel Kv1.5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

cytoskeletal protein binding

1 reference

8 April 2019

DLG1: chromosome location of the closest human homologue of the Drosophila discs large tumor suppressor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

protein C-terminus binding

1 reference

8 April 2019

Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

ionotropic glutamate receptor binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

mitogen-activated protein kinase kinase binding

1 reference

8 April 2019

Identification of mitogen-activated protein/extracellular signal-responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc-large

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

guanylate kinase activity

1 reference

8 April 2019

Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

protein binding

25 references

8 April 2019

GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Proteome-wide analysis of phospho-regulated PDZ domain interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Association of cottontail rabbit papillomavirus E6 oncoproteins with the hDlg/SAP97 tumor suppressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Solution structure of the hDlg/SAP97 PDZ2 domain and its mechanism of interaction with HPV-18 papillomavirus E6 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Identification of SAP97 as an intracellular binding partner of TACE

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

The multiple-specificity landscape of modular peptide recognition domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Chimaeric HPV E6 proteins allow dissection of the proteolytic pathways regulating different E6 cellular target proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Identification of mitogen-activated protein/extracellular signal-responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc-large

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Role of the PDZ domain-binding motif of the oncoprotein E6 in the pathogenesis of human papillomavirus type 31

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Quantitative Mass Spectrometry Identifies Novel Host Binding Partners for Pathogenic Escherichia coli Type III Secretion System Effectors.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

protein kinase binding

3 references

8 April 2019

Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Characterization of PDZ-binding kinase, a mitotic kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

L27 domain binding

1 reference

8 April 2019

The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

ligand-gated ion channel activity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q12959

1 reference

14 February 2017

potassium channel regulator activity

Characterization of PDZ-binding kinase, a mitotic kinase

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

NAS

8 April 2019

Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Different isoforms of synapse-associated protein, SAP97, are expressed in the heart and have distinct effects on the voltage-gated K+ channel Kv1.5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

cadherin binding

1 reference

14 February 2017

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q12959

cadherin binding

1 reference

8 April 2019

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

structural constituent of postsynaptic density

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

cell component

cytoplasm

2 references

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

1 reference

8 April 2019

postsynaptic membrane

2 references

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

1 reference

8 April 2019

cell-cell junction

1 reference

8 April 2019

Identification of mitogen-activated protein/extracellular signal-responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc-large

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

bicellular tight junction

1 reference

8 April 2019

The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

node of Ranvier

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

perinuclear region of cytoplasm

1 reference

8 April 2019

Identification of mitogen-activated protein/extracellular signal-responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc-large

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

cytoplasmic side of plasma membrane

1 reference

8 April 2019

Identification of mitogen-activated protein/extracellular signal-responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc-large

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

microtubule

1 reference

8 April 2019

Identification of mitogen-activated protein/extracellular signal-responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc-large

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

nucleus

1 reference

8 April 2019

The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

cell projection membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

membrane raft

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

ionotropic glutamate receptor complex

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

extracellular exosome

1 reference

14 February 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q12959

Golgi apparatus

1 reference

8 April 2019

Identification of mitogen-activated protein/extracellular signal-responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc-large

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

lateral plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

intercalated disc

1 reference

8 April 2019

SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

neuromuscular junction

1 reference

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q12959

myelin sheath abaxonal region

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

lateral loop

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

endoplasmic reticulum membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

1 reference

8 April 2019

MPP7-DLG1-LIN7 complex

1 reference

8 April 2019

The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

sarcolemma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

1 reference

8 April 2019

postsynaptic density

3 references

cell junction

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q12959

4 references

14 February 2017

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q12959

14 February 2017

Myo6 facilitates the translocation of endocytic vesicles from cell peripheries

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q12959

14 February 2017

The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q12959

basolateral plasma membrane

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q12959

3 references

14 February 2017

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q12959

14 February 2017

Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q12959

plasma membrane

immunological synapse

Localization of Kv1.3 channels in the immunological synapse modulates the calcium response to antigen stimulation in T lymphocytes

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

basement membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

3 references

8 April 2019

8 April 2019

Identification of mitogen-activated protein/extracellular signal-responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc-large

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

basolateral plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

apical plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

1 reference

8 April 2019

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

5 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Myo6 facilitates the translocation of endocytic vesicles from cell peripheries

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

neuron projection

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

postsynaptic membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

1 reference

8 April 2019

extracellular exosome

1 reference

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

postsynaptic density membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

glutamatergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

embryonic skeletal system morphogenesis

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

ureteric bud development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

positive regulation of actin filament polymerization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

positive regulation of potassium ion transport

1 reference

8 April 2019

Different isoforms of synapse-associated protein, SAP97, are expressed in the heart and have distinct effects on the voltage-gated K+ channel Kv1.5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

negative regulation of p38MAPK cascade

1 reference

8 April 2019

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

amyloid precursor protein metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

tissue morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

reproductive structure development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

membrane raft organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

hard palate development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

endothelial cell proliferation

1 reference

8 April 2019

Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

smooth muscle tissue development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

negative regulation of epithelial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

regulation of sodium ion transmembrane transport

1 reference

8 April 2019

SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

astral microtubule organization

1 reference

8 April 2019

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

actin filament organization

1 reference

8 April 2019

Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

mitotic cell cycle checkpoint signaling

NAS

1 reference

8 April 2019

The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

NAS

receptor clustering

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

establishment or maintenance of cell polarity

1 reference

8 April 2019

Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

negative regulation of T cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

branching involved in ureteric bud morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

regulation of myelination

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

cortical microtubule organization

1 reference

8 April 2019

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

establishment or maintenance of epithelial cell apical/basal polarity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

viral process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

1 reference

8 April 2019

T cell cytokine production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

T cell activation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

peristalsis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

receptor localization to synapse

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

negative regulation of protein kinase B signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

regulation of NIK/NF-kappaB signaling

1 reference

8 April 2019

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

negative regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

nervous system development

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q12959

1 reference

14 February 2017

regulation of cell shape

1 reference

8 April 2019

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

establishment of centrosome localization

1 reference

8 April 2019

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

immunological synapse formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

cortical actin cytoskeleton organization

1 reference

8 April 2019

Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

protein localization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

lens development in camera-type eye

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

bicellular tight junction assembly

1 reference

8 April 2019

The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

positive regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

negative regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

activation of protein kinase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

negative regulation of mitotic cell cycle

1 reference

8 April 2019

The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

protein localization to plasma membrane

GDP metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

ion transmembrane transport

1 reference

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q12959

protein dephosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

GMP metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

chemical synaptic transmission

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

MAPK cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

1 reference

8 April 2019

cell-cell adhesion

maintenance of postsynaptic density structure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

neurotransmitter receptor localization to postsynaptic specialization membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

positive regulation of protein localization to plasma membrane

1 reference

8 April 2019

Different isoforms of synapse-associated protein, SAP97, are expressed in the heart and have distinct effects on the voltage-gated K+ channel Kv1.5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

regulation of NMDA receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959

1 reference

8 April 2019

1 reference

Guanylate kinase/L-type calcium channel beta subunit

1 reference

SH3 domain

1 reference

Guanylate kinase-like domain

1 reference

PDZ-associated domain of NMDA receptors

1 reference

L27 domain

1 reference

L27-1

1 reference

Guanylate kinase, conserved site

1 reference

Disks large homologue 1, N-terminal PEST domain

1 reference

D08.811.913.696.650.450.500

Identifiers

MeSH descriptor ID

D000074288

subject named as

Discs Large Homolog 1 Protein

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MeSH tree code

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7 December 2018

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30 June 2016

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30 June 2016

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30 June 2016

Transporter Classification Database ID

English

8.A.24.1.7

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023