Heat shock protein 90 alpha family class B member 1 (Q21132860)

From Wikidata
Jump to navigation Jump to search
mammalian protein found in Homo sapiens
  • heat shock 90kD protein 1, beta
  • heat shock protein 90kDa alpha family class B member 1
  • heat shock protein 90 kDa
  • heat shock protein HSP 90-beta
  • HSP 84
  • heat shock 84 kDa
  • heat shock protein 90kDa alpha (cytosolic), class B member 1
  • HSP84
  • HSP90AB1
  • HSP90-beta
edit
Language Label Description Also known as
English
Heat shock protein 90 alpha family class B member 1
mammalian protein found in Homo sapiens
  • heat shock 90kD protein 1, beta
  • heat shock protein 90kDa alpha family class B member 1
  • heat shock protein 90 kDa
  • heat shock protein HSP 90-beta
  • HSP 84
  • heat shock 84 kDa
  • heat shock protein 90kDa alpha (cytosolic), class B member 1
  • HSP84
  • HSP90AB1
  • HSP90-beta

Statements

molecular function
protein binding
determination method
IPI
54 references
retrieved
8 April 2019
stated in
Distinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channels
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of Hsp90 with ribosomal proteins protects from ubiquitination and proteasome-dependent degradation
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Middle domain of human Hsp90 isoforms differentially binds Aha1 in human cells and alters Hsp90 activity in yeast
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Hsp70 and Hsp90 oppositely regulate TGF-β signaling through CHIP/Stub1
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
SGT, a Hsp90beta binding partner, is accumulated in the nucleus during cell apoptosis
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation analysis of 90 kDa heat shock protein within the cytosolic arylhydrocarbon receptor complex
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
XAP2 inhibits glucocorticoid receptor activity in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Hepatitis B virus polymerase suppresses NF-κB signaling by inhibiting the activity of IKKs via interaction with Hsp90β
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
CHIP interacts with heat shock factor 1 during heat stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of pro-apoptotic protein HGTD-P with heat shock protein 90 is required for induction of mitochondrial apoptotic cascades
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Hsp90-Tau complex reveals molecular basis for specificity in chaperone action
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
The human TPR protein TTC4 is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
N-terminal domain of human Hsp90 triggers binding to the cochaperone p23.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
8 April 2019
stated in
The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
protein binding
determination method
IBA
IPI
54 references
retrieved
1 January 2018
stated in
An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Phosphorylation analysis of 90 kDa heat shock protein within the cytosolic arylhydrocarbon receptor complex
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Hsp70 and Hsp90 oppositely regulate TGF-β signaling through CHIP/Stub1
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Middle domain of human Hsp90 isoforms differentially binds Aha1 in human cells and alters Hsp90 activity in yeast
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Distinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channels
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Interaction of Hsp90 with ribosomal proteins protects from ubiquitination and proteasome-dependent degradation
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
SGT, a Hsp90beta binding partner, is accumulated in the nucleus during cell apoptosis
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Hepatitis B virus polymerase suppresses NF-κB signaling by inhibiting the activity of IKKs via interaction with Hsp90β
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
N-terminal domain of human Hsp90 triggers binding to the cochaperone p23.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
XAP2 inhibits glucocorticoid receptor activity in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Hsp90-Tau complex reveals molecular basis for specificity in chaperone action
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
The human TPR protein TTC4 is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Interaction of pro-apoptotic protein HGTD-P with heat shock protein 90 is required for induction of mitochondrial apoptotic cascades
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
CHIP interacts with heat shock factor 1 during heat stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IPI
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IBA
cell component
cytoplasm
determination method
IDA
IEA
7 references
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P08238&geneProductId=UniProtKB:P08238
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P08238&geneProductId=UniProtKB:P08238
determination method
IEA
retrieved
17 October 2017
stated in
SGT, a Hsp90beta binding partner, is accumulated in the nucleus during cell apoptosis
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P08238&geneProductId=UniProtKB:P08238
determination method
IDA
retrieved
17 October 2017
stated in
Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P08238&geneProductId=UniProtKB:P08238
determination method
IDA
retrieved
17 October 2017
stated in
SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P08238&geneProductId=UniProtKB:P08238
determination method
IDA
retrieved
17 October 2017
stated in
HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P08238&geneProductId=UniProtKB:P08238
determination method
IDA
retrieved
17 October 2017
stated in
Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P08238&geneProductId=UniProtKB:P08238
determination method
IDA
cytoplasm
determination method
IBA
IDA
IEA
8 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IEA
retrieved
8 April 2019
stated in
Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IDA
retrieved
8 April 2019
stated in
SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IDA
retrieved
8 April 2019
stated in
SGT, a Hsp90beta binding partner, is accumulated in the nucleus during cell apoptosis
GOA
curator
UniProt
UniProt protein ID
P08238
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IDA
retrieved
8 April 2019
stated in
Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IDA
retrieved
8 April 2019
stated in
HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08238
determination method
IBA
biological process

Identifiers

 
edit
    edit
      edit
        edit
          edit
            edit
              edit
                edit
                  edit
                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21132860&oldid=2023018465"