S-phase kinase associated protein 2 (Q21151769)

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mammalian protein found in Homo sapiens

F-box protein Skp2
F-box/LRR-repeat protein 1
SKP2
S-phase kinase-associated protein 2
CDK2/cyclin A-associated protein p45
p45skp2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
Cyclin-A/CDK2-associated protein p45
SKP2 protein, human

Language	Label	Description	Also known as
English	S-phase kinase associated protein 2	mammalian protein found in Homo sapiens	F-box protein Skp2 F-box/LRR-repeat protein 1 SKP2 S-phase kinase-associated protein 2 CDK2/cyclin A-associated protein p45 p45skp2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase Cyclin-A/CDK2-associated protein p45 SKP2 protein, human

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

Leucine-rich repeat domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13309

F-box-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13309

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, cysteine-containing subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

ubiquitin protein ligase activity

determination method

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13309&geneProductId=UniProtKB:Q13309

determination method

protein binding

determination method

20 references

1 January 2018

Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

Acetylation-dependent regulation of Skp2 function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c-Myc

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

A negatively charged amino acid in Skp2 is required for Skp2-Cks1 interaction and ubiquitination of p27Kip1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

TIP120A associates with cullins and modulates ubiquitin ligase activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

A High-Density Map for Navigating the Human Polycomb Complexome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

identical protein binding

determination method

1 reference

1 January 2018

Acetylation-dependent regulation of Skp2 function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

determination method

1 reference

1 January 2018

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

determination method

3 references

determination method

SCF ubiquitin ligase complex

determination method

3 references

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

biological process

regulation of apoptotic process

determination method

1 reference

1 January 2018

Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

cellular response to cell-matrix adhesion

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

positive regulation of intracellular estrogen receptor signaling pathway

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

ubiquitin-dependent protein catabolic process

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

regulation of cell cycle

determination method

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13309&geneProductId=UniProtKB:Q13309

determination method

G2/M transition of mitotic cell cycle

determination method

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13309&geneProductId=UniProtKB:Q13309

determination method

protein ubiquitination

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

positive regulation of protein polyubiquitination

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

cell population proliferation

determination method

1 reference

1 January 2018

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

positive regulation of smooth muscle cell proliferation

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

protein deubiquitination

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

post-translational protein modification

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

proteasome-mediated ubiquitin-dependent protein catabolic process

determination method

1 reference

1 January 2018

ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

innate immune response

determination method

1 reference

10 September 2018

ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13309&geneProductId=UniProtKB:Q13309

determination method

defense response to virus

determination method

1 reference

10 September 2018

ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13309&geneProductId=UniProtKB:Q13309

determination method

protein K48-linked ubiquitination

determination method

1 reference

1 January 2018

ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

immune system process

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13309

Leucine-rich repeat, cysteine-containing subtype

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13309

Identifiers

MeSH descriptor ID

subject named as

SKP2 protein, human

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000274254

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000274254

ENSP00000274255

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000274255

ENSP00000478031

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000478031

ENSP00000421941

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421941

ENSP00000423188

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000423188

ENSP00000424234

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000424234

ENSP00000426004

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000426004

ENSP00000426675

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000426675

ENSP00000443492

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000443492

PDB structure ID

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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