Acetylation-dependent regulation of Skp2 function (Q24292805)

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Cadherin 1

1 reference

GOA release 2020-03-11

author

Pier Paolo Pandolfi

17

0 references

Julie Teruya-Feldstein

14

0 references

Steven P. Gygi

12

Steven P Gygi

0 references

Lydia Finley

3

Lydia W S Finley

0 references

Hiroyuki Inuzuka

1

Hiroyuki Inuzuka

0 references

Wenyi Wei

18

Wenyi Wei

0 references

Lixin Wan

5

Lixin Wan

0 references

Shavali Shaik

9

Shavali Shaik

0 references

Hidefumi Fukushima

6

Hidefumi Fukushima

0 references

Marcia C. Haigis

16

Marcia C Haigis

0 references

author name string

Daming Gao

2

0 references

Wen Yang

4

0 references

Y Rebecca Chin

7

0 references

Bo Zhai

8

0 references

Alan W Lau

10

0 references

Zhiwei Wang

11

0 references

Keiko Nakayama

13

0 references

Alex Toker

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

15

0 references

language of work or name

English

0 references

publication date

6 July 2012

0 references

published in

Cell

0 references

volume

150

0 references

page(s)

179-93

0 references

issue

1

0 references

cites work

1 reference

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Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

19 March 2017

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Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

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Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

19 March 2017

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Acetylation-dependent signal transduction for type I interferon receptor

19 March 2017

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Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation

19 March 2017

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The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription

19 March 2017

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

19 March 2017

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

19 March 2017

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Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

19 March 2017

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The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase

19 March 2017

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

19 March 2017

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Regulation of chromatin structure by site-specific histone H3 methyltransferases

19 March 2017

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

19 March 2017

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Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination

19 March 2017

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SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

19 March 2017

1 reference

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Differential expression of the F-box proteins Skp2 and Skp2B in breast cancer

19 March 2017

1 reference

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The SCF ubiquitin ligase: insights into a molecular machine

19 March 2017

1 reference

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Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

19 March 2017

1 reference

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Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase

19 March 2017

1 reference

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Mammalian SIRT1 represses forkhead transcription factors

19 March 2017

1 reference

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Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

19 March 2017

1 reference

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Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation

19 March 2017

1 reference

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Mammalian sirtuins: biological insights and disease relevance

19 March 2017

1 reference

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Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

7 April 2017

1 reference

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Murine Sirt3 protein isoforms have variable half-lives

27 September 2017

1 reference

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SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization

27 September 2017

1 reference

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SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

27 September 2017

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Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms

27 September 2017

1 reference

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FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states

27 September 2017

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E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer

27 September 2017

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Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer

27 September 2017

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Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease

27 September 2017

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Microenvironmental regulation of E-cadherin-mediated adherens junctions

27 September 2017

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Skp2 suppresses p53-dependent apoptosis by inhibiting p300.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

The human SIRT3 protein deacetylase is exclusively mitochondrial

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Knockdown of S-phase kinase-associated protein-2 expression in MCF-7 inhibits cell growth and enhances the cytotoxic effects of epirubicin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Casein kinase 1 is a novel negative regulator of E-cadherin-based cell-cell contacts

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Fbw7/hCDC4 dimerization regulates its substrate interactions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

c-Abl acetylation by histone acetyltransferases regulates its nuclear-cytoplasmic localization

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Regulation of nuclear transport: central role in development and transformation?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Stat3 dimerization regulated by reversible acetylation of a single lysine residue

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression

27 September 2017

1 reference

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Targeting the PI3K-Akt pathway in human cancer: rationale and promise

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Regulation of tumor suppressors by nuclear-cytoplasmic shuttling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Skp2 is oncogenic and overexpressed in human cancers

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Multiple roles for acetylation in the interaction of p300 HAT with ATF-2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

F-box protein Skp2: a novel transcriptional target of E2F.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Skip the nucleus, AKT drives Skp2 and FOXO1 to the same place?

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Prognostic impact of Skp2 and p27 in human breast cancer.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Altered expression of p27 and Skp2 proteins in prostate cancer of African-American patients.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Overexpression of Skp2 in carcinoma of the cervix does not correlate inversely with p27 expression

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595190

Expression of Skp2, a p27(Kip1) ubiquitin ligase, in malignant lymphoma: correlation with p27(Kip1) and proliferation index

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22770219

12 December 2020

inferred from PubMed ID database lookup

PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2)

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22770219

12 December 2020

inferred from PubMed ID database lookup

Differentiation between senescence (M1) and crisis (M2) in human fibroblast cultures

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7 January 2021

Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.038

7 January 2021

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

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7 January 2021

SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle

1 reference

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7 January 2021

Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

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7 January 2021

Identification of substrates for F-box proteins

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7 January 2021

FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function

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https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.038

7 January 2021

SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

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7 January 2021

Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts

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7 January 2021

Mitochondrial longevity in vitro: the retention of respiratory control

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.038

7 January 2021

"Survival" of mitochondria in vitro: physical and energy parameters

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.038

7 January 2021

Transformation of human and murine fibroblasts without viral oncoproteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.038

7 January 2021

Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.038

7 January 2021

10.1016/J.CELL.2012.05.038

Identifiers

DOI

1 reference

1841524

1841524

1 reference

1 reference

1 reference