Heat shock protein 5 (Q21495560)

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mammalian protein found in Mus musculus
  • binding-immunoglobulin protein
  • endoplasmic reticulum chaperone BiP
  • HSP70 family protein 5
  • BiP
  • immunoglobulin heavy chain-binding protein
  • heat shock protein 70 family protein 5
  • glucose regulated protein, 78 kDa
  • heat shock 70 kDa protein 5
  • GRP-78
  • 78 kDa glucose-regulated protein
  • XAP-1 antigen
  • heat shock protein family A member 5
  • heat shock 70kD protein 5 (glucose-regulated protein, 78kD)
  • Hspa5
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Language Label Description Also known as
English
Heat shock protein 5
mammalian protein found in Mus musculus
  • binding-immunoglobulin protein
  • endoplasmic reticulum chaperone BiP
  • HSP70 family protein 5
  • BiP
  • immunoglobulin heavy chain-binding protein
  • heat shock protein 70 family protein 5
  • glucose regulated protein, 78 kDa
  • heat shock 70 kDa protein 5
  • GRP-78
  • 78 kDa glucose-regulated protein
  • XAP-1 antigen
  • heat shock protein family A member 5
  • heat shock 70kD protein 5 (glucose-regulated protein, 78kD)
  • Hspa5

Statements

molecular function
protein binding
determination method
IPI
13 references
retrieved
14 February 2019
stated in
Identification and characterization of a novel endoplasmic reticulum (ER) DnaJ homologue, which stimulates ATPase activity of BiP in vitro and is induced by ER stress
GOA
curator
UniProt
UniProt protein ID
P20029
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IPI
retrieved
14 February 2019
stated in
Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IPI
retrieved
14 February 2019
stated in
Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IPI
retrieved
14 February 2019
stated in
A novel type of co-chaperone mediates transmembrane recruitment of DnaK-like chaperones to ribosomes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IPI
retrieved
14 February 2019
stated in
Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IPI
retrieved
14 February 2019
stated in
RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IPI
retrieved
14 February 2019
stated in
The mouse FKBP23 binds to BiP in ER and the binding of C-terminal domain is interrelated with Ca2+ concentration
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IPI
retrieved
14 February 2019
stated in
GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IPI
retrieved
14 February 2019
stated in
Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IPI
retrieved
14 February 2019
stated in
Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IPI
retrieved
14 February 2019
stated in
Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IPI
retrieved
14 February 2019
stated in
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IPI
retrieved
14 February 2019
stated in
Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IPI
cell component
endoplasmic reticulum
determination method
IDA
IEA
ISO
17 references
retrieved
14 February 2019
stated in
The C-terminal region of cis-retinol/androgen dehydrogenase 1 (CRAD1) confers ER localization and in vivo enzymatic function
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
ISO
retrieved
14 February 2019
stated in
UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P20029
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IEA
retrieved
14 February 2019
stated in
Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IDA
retrieved
14 February 2019
stated in
Mice lacking the MHC class II-associated invariant chain
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IDA
retrieved
14 February 2019
stated in
Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IDA
retrieved
14 February 2019
stated in
Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IDA
retrieved
14 February 2019
stated in
The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human β-cells and its targeted inactivation impairs glucose tolerance
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IDA
retrieved
14 February 2019
stated in
Endoplasmic reticulum-associated degradation-induced dissociation of class II invariant chain complexes containing a glycosylation-deficient form of p41
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IDA
retrieved
14 February 2019
stated in
Goofy coordinates the acuity of olfactory signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IDA
retrieved
14 February 2019
stated in
Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IDA
retrieved
14 February 2019
stated in
Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IDA
retrieved
14 February 2019
stated in
Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IDA
retrieved
14 February 2019
stated in
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IDA
retrieved
14 February 2019
stated in
The mouse FKBP23 binds to BiP in ER and the binding of C-terminal domain is interrelated with Ca2+ concentration
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IDA
retrieved
14 February 2019
stated in
PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20029
determination method
IDA
biological process

Identifiers

 
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