Mitogen-activated protein kinase kinase kinase 7 (Q21985570)

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mammalian protein found in Mus musculus

TGF-beta-activated kinase 1
Map3k7
mitogen-activated protein kinase kinase kinase 7
transforming growth factor-beta-activated kinase 1

Language	Label	Description	Also known as
English	Mitogen-activated protein kinase kinase kinase 7	mammalian protein found in Mus musculus	TGF-beta-activated kinase 1 Map3k7 mitogen-activated protein kinase kinase kinase 7 transforming growth factor-beta-activated kinase 1

Statements

1 reference

25 May 2022

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62073

mitogen-activated protein (MAP) kinase kinase kinase 7

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62073

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

nucleotide binding

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

protein kinase activity

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

scaffold protein binding

determination method

1 reference

14 February 2019

SASH1 is a scaffold molecule in endothelial TLR4 signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

metal ion binding

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

kinase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

protein binding

determination method

12 references

14 February 2019

Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

14 February 2019

PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

14 February 2019

Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

14 February 2019

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

14 February 2019

TAK1 is an essential regulator of BMP signalling in cartilage

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

14 February 2019

TAK1-dependent signaling requires functional interaction with TAB2/TAB3

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

14 February 2019

HSP90 is required for TAK1 stability but not for its activation in the pro-inflammatory signaling pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

14 February 2019

USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

14 February 2019

GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

14 February 2019

Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

14 February 2019

Direct activation of protein kinases by unanchored polyubiquitin chains

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

14 February 2019

The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

MAP kinase kinase kinase activity

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

determination method

2 references

MAP kinase kinase activity

determination method

1 reference

14 February 2019

Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

magnesium ion binding

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

protein serine/threonine kinase activity

determination method

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

14 February 2019

Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

receptor tyrosine kinase binding

determination method

1 reference

14 February 2019

Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

plasma membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

postsynaptic density

determination method

1 reference

14 February 2019

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

intracellular anatomical structure

determination method

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62073&geneProductId=UniProtKB:Q62073

determination method

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

biological process

regulation of transcription, DNA-templated

determination method

1 reference

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62073&geneProductId=UniProtKB:Q62073

determination method

negative regulation of ripoptosome assembly involved in necroptotic process

determination method

1 reference

14 February 2019

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

phosphorylation

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

negative regulation of necroptotic process

determination method

1 reference

14 February 2019

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

positive regulation of JUN kinase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

positive regulation of JNK cascade

determination method

1 reference

14 February 2019

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

regulation of reactive oxygen species metabolic process

determination method

1 reference

14 February 2019

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

transcription, DNA-templated

determination method

1 reference

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62073&geneProductId=UniProtKB:Q62073

determination method

determination method

1 reference

14 February 2019

Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

determination method

1 reference

14 February 2019

The TGF beta activated kinase TAK1 regulates vascular development in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method

1 reference

21 June 2018

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62073&geneProductId=UniProtKB:Q62073

determination method

negative regulation of reactive oxygen species metabolic process

determination method

1 reference

14 February 2019

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

transforming growth factor beta receptor signaling pathway

determination method

1 reference

14 February 2019

Short-term lineage analysis of dorsally derived Olig3 cells in the developing spinal cord

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

neural tube formation

determination method

1 reference

14 February 2019

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

apoptotic process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

positive regulation of macroautophagy

determination method

1 reference

14 February 2019

IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

determination method

1 reference

14 February 2019

IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

signal transduction

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

peptidyl-threonine phosphorylation

determination method

1 reference

14 February 2019

Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62073

determination method

determination method

1 reference

21 June 2018

The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62073&geneProductId=UniProtKB:Q62073

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000079734

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000079734

ENSMUSP00000040307

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000040307

ENSMUSP00000103818

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000103818

ENSMUSP00000103819

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000103819

Sitelinks

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Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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