TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis (Q24293476)

GOA release 2020-03-11

James H Felce

13

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Falk Butter

Falk Butter

6

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Calliope A. Dendrou

Calliope A Dendrou

2

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Gilean McVean

Gil McVean

20

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Ralf Gold

15

Ralf Gold

0 references

Lars Fugger

21

Lars Fugger

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Gereon Poschmann

7

Gereon Poschmann

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author name string

Adam P Gregory

1

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Kathrine E Attfield

3

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Aiden Haghikia

4

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Dionysia K Xifara

5

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Gurman Kaur

8

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Lydia Lambert

9

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Oliver A Leach

10

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Simone Prömel

11

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Divya Punwani

12

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Simon J Davis

14

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Finn C Nielsen

16

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Richard M Siegel

17

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Matthias Mann

18

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John I Bell

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

19

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language of work or name

English

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publication date

23 August 2012

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published in

Nature

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volume

488

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page(s)

508-11

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issue

7412

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cites work

1 reference

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Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

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Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination

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Regulation of TNFR1 and CD95 signalling by receptor compartmentalization

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Falling into TRAPS--receptor misfolding in the TNF receptor 1-associated periodic fever syndrome

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TNFR1 signalling is critical for the development of demyelination and the limitation of T-cell responses during immune-mediated CNS disease

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27 September 2017

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Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis

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Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB.

30 May 2018

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TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination.

29 November 2018

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Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins

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1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22801493

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22801493

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A rigorous experimental framework for detecting protein oligomerization using bioluminescence resonance energy transfer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22801493

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE11307

1 reference

Dimensions Publication ID

43078

1011438914

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43078

1 reference

1 reference

1 reference