PRAK is essential for ras-induced senescence and tumor suppression (Q24294592)

stress-induced premature senescence

GOA release 2020-03-11

1 reference

MAP kinase-activated protein kinase 5

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

14

Peter E Wright

Peter E

Wright

1 reference

26 October 2023

Peiqing Sun

1

Peiqing

Sun

1 reference

26 October 2023

Naoto Yoshizuka

2

Naoto

Yoshizuka

1 reference

26 October 2023

Liguo New

3

Liguo

New

1 reference

26 October 2023

Bettina A Moser

4

Bettina A

Moser

1 reference

26 October 2023

Yilei Li

5

Yilei

Li

1 reference

26 October 2023

Rong Liao

6

Rong

Liao

1 reference

26 October 2023

Changchuan Xie

7

Changchuan

Xie

1 reference

26 October 2023

Jianming Chen

8

Jianming

Chen

1 reference

26 October 2023

Qingdong Deng

9

Qingdong

Deng

1 reference

26 October 2023

Maria Yamout

10

Maria

Yamout

1 reference

26 October 2023

Meng-Qiu Dong

11

Meng-Qiu

Dong

1 reference

26 October 2023

Costas G Frangou

12

Costas G

Frangou

1 reference

26 October 2023

John R Yates

13

John R 3rd

Yates

1 reference

26 October 2023

Jiahuai Han

15

Jiahuai

Han

1 reference

Multistage carcinogenesis in mouse skin

26 October 2023

language of work or name

English

0 references

publication date

26 January 2007

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published in

Cell

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volume

128

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issue

2

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page(s)

295-308

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cites work

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

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Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway

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Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

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Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway

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High Intensity ras Signaling Induces Premature Senescence by Activating p38 Pathway in Primary Human Fibroblasts

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PRAK, a novel protein kinase regulated by the p38 MAP kinase

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Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

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Senescence of human fibroblasts induced by oncogenic Raf.

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Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

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The ability of E1A to rescue ras-induced premature senescence and confer transformation relies on inactivation of both p300/CBP and Rb family proteins

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