Oncogenic ras and p53 cooperate to induce cellular senescence (Q34279104)

1 August 2017

title

Oncogenic ras and p53 cooperate to induce cellular senescence (English)

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1 August 2017

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2

Elisa de Stanchina

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Gregory Hannon

6

object named as

Gregory J Hannon

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1 August 2017

Gerardo Ferbeyre

1

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1 August 2017

Athena W Lin

3

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1 August 2017

Emmanuelle Querido

4

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1 August 2017

Mila E McCurrach

5

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1 August 2017

Scott W Lowe

7

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1 August 2017

language of work or name

English

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publication date

1 May 2002

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Molecular and Cellular Biology

1 August 2017

published in

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1 August 2017

volume

22

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1 August 2017

issue

10

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1 August 2017

page(s)

3497-3508

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Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

1 August 2017

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6 July 2018

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PML is induced by oncogenic ras and promotes premature senescence

6 July 2018

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PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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SUMO-1 modification activates the transcriptional response of p53

6 July 2018

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Nucleolar Arf sequesters Mdm2 and activates p53

6 July 2018

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6 July 2018

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P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

6 July 2018

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6 July 2018

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Induced p53 expression in lung cancer cell line promotes cell senescence and differentially modifies the cytotoxicity of anti-cancer drugs

6 July 2018

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Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

6 July 2018

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6 July 2018

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6 July 2018

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E1A signaling to p53 involves the p19(ARF) tumor suppressor

6 July 2018

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

6 July 2018

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6 July 2018

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Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

6 July 2018

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

6 July 2018

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

6 July 2018

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Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation

6 July 2018

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Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53.

6 July 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

6 July 2018

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A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

6 July 2018

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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

6 July 2018

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p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

6 July 2018

1 reference

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Redox modulation of p53 conformation and sequence-specific DNA binding in vitro.

6 July 2018

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Use of a conditional MyoD transcription factor in studies of MyoD trans-activation and muscle determination

6 July 2018

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Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

6 July 2018

1 reference

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Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

The p53-mdm-2 autoregulatory feedback loop

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

p53 and E2F-1 cooperate to mediate apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

Mediation of c-Myc-induced apoptosis by p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

Role of cysteine residues in regulation of p53 function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

Cytokines inhibit p53-mediated apoptosis but not p53-mediated G1 arrest

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

Identification of p53 as a sequence-specific DNA-binding protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

Wild-type p53 can down-modulate the activity of various promoters

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

A transactivation-deficient mouse model provides insights into Trp53 regulation and function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

Cellular adhesion regulates p53 protein levels in primary human keratinocytes.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

p19ARF links the tumour suppressor p53 to Ras

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133786

A p53-dependent mouse spindle checkpoint

28 October 2018

1 reference

12 December 2020

Phosphorylation of p53 serine 15 increases interaction with CBP

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12 December 2020

Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage

1 reference

12 December 2020

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

1 reference

12 December 2020

10.1128/MCB.22.10.3497-3508.2002

Identifiers

DOI

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1 August 2017

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1 August 2017

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