Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator (Q24294798)

brown fat cell differentiation

Europe PubMed Central

title

Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator (English)

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main subject

2 references

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0050873

PPARG coactivator 1 alpha

GOA release 2020-03-11

1 reference

Peroxisome proliferator activated receptor gamma

GOA release 2020-03-11

1 reference

UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue

GOA release 2020-03-11

author

Pere Puigserver

series ordinal

1

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Bruce Spiegelman

series ordinal

2

object named as

Bruce M Spiegelman

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language of work or name

English

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publication date

February 2003

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published in

Endocrine Reviews

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volume

24

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page(s)

78-90

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issue

1

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cites work

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Whole-body energy metabolism and skeletal muscle biochemical characteristics

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Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression

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Signal transduction by the JNK group of MAP kinases

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Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

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A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

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Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

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FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance

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Rapid in vivo PGC-1 mRNA upregulation in brown adipose tissue of Wistar rats by a beta(3)-adrenergic agonist and lack of effect of leptin

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Multiple signals converging on NF-kappaB.

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A CTD function linking transcription to splicing

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7 January 2021

Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1

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PPAR gamma is required for placental, cardiac, and adipose tissue development

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PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

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Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.

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A role for brown adipose tissue in diet-induced thermogenesis

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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

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CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

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Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese

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Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis

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A signature motif in transcriptional co-activators mediates binding to nuclear receptors

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Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

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Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

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Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.

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Thyroid hormone and other regulators of uncoupling proteins

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Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.

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Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor

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The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins

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A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program

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Activation of the nuclear receptor peroxisome proliferator-activated receptor gamma promotes brown adipocyte differentiation

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7 January 2021

Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin

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Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor

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7 January 2021

Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1

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7 January 2021

Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell.

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7 January 2021

p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: a potential role in the cardiac metabolic stress response

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7 January 2021

PGC-1 functions as a transcriptional coactivator for the retinoid X receptors

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7 January 2021

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7 January 2021

Energy metabolism in uncoupling protein 3 gene knockout mice

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7 January 2021

Molecular biology of brown adipose tissue

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7 January 2021

Thyroid hormone control of thermogenesis and energy balance

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7 January 2021

Genetic studies of brown adipocyte induction

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7 January 2021

Transcription units as RNA processing units

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Brown adipose tissue. More than an effector of thermogenesis?

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7 January 2021

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7 January 2021

Activation of PPARgamma coactivator-1 through transcription factor docking

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7 January 2021

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

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7 January 2021

An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene

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7 January 2021

Differentiation-dependent expression of the brown adipocyte uncoupling protein gene: regulation by peroxisome proliferator-activated receptor gamma

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7 January 2021

Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta

1 reference

https://api.crossref.org/works/10.1210%2FER.2002-0012

7 January 2021

8-Bromo-cyclic AMP induces phosphorylation of two sites in SRC-1 that facilitate ligand-independent activation of the chicken progesterone receptor and are critical for functional cooperation between SRC-1 and CREB binding protein

1 reference

https://api.crossref.org/works/10.1210%2FER.2002-0012

7 January 2021

The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes

1 reference

https://api.crossref.org/works/10.1210%2FER.2002-0012

7 January 2021

A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen

1 reference

https://api.crossref.org/works/10.1210%2FER.2002-0012

7 January 2021

1 reference

https://api.crossref.org/works/10.1210%2FER.2002-0012

7 January 2021

Transcriptional coactivator complexes

1 reference

https://api.crossref.org/works/10.1210%2FER.2002-0012

7 January 2021

Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis

1 reference

https://api.crossref.org/works/10.1210%2FER.2002-0012

7 January 2021

Skeletal muscle metabolism is a major determinant of resting energy expenditure

1 reference

https://api.crossref.org/works/10.1210%2FER.2002-0012

7 January 2021

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

1 reference

https://api.crossref.org/works/10.1210%2FER.2002-0012

7 January 2021