Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression (Q24297027)

RB binding protein 5, histone lysine methyltransferase complex subunit

1 reference

ASH2 like, histone lysine methyltransferase complex subunit

1 reference

UTP18 small subunit processome component

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menin

1 reference

1 reference

Mrinmoy Sanyal

4

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Winship Herr

object named as

Winship Herr

7

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author name string

Akihiko Yokoyama

1

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Zhong Wang

2

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Joanna Wysocka

3

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Deborah J Aufiero

5

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Issay Kitabayashi

6

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Michael L Cleary

Molecular and Cellular Biology

8

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language of work or name

English

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publication date

July 2004

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published in

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volume

24

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page(s)

5639-49

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issue

13

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cites work

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

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Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression

19 March 2017

1 reference

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HCF-1 functions as a coactivator for the zinc finger protein Krox20

19 March 2017

1 reference

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Menin associates with FANCD2, a protein involved in repair of DNA damage

19 March 2017

1 reference

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Multiple tumor suppressor pathways negatively regulate telomerase

19 March 2017

1 reference

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MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein

19 March 2017

1 reference

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Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1

19 March 2017

1 reference

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The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene

19 March 2017

1 reference

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Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

19 March 2017

1 reference

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Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins

19 March 2017

1 reference

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Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

19 March 2017

1 reference

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A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3

19 March 2017

1 reference

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The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4

19 March 2017

1 reference

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ASH2L: alternative splicing and downregulation during induced megakaryocytic differentiation of multipotential leukemia cell lines

19 March 2017

1 reference

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MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

19 March 2017

1 reference

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Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9

19 March 2017

1 reference

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Cloning and characterization of ASH2L and Ash2l, human and mouse homologs of the Drosophila ash2 gene

19 March 2017

1 reference

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Herpes simplex virus transactivator VP16 discriminates between HCF-1 and a novel family member, HCF-2.

19 March 2017

1 reference

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Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF

19 March 2017

1 reference

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Association of SET domain and myotubularin-related proteins modulates growth control

19 March 2017

1 reference

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Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP

19 March 2017

1 reference

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The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides

19 March 2017

1 reference

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Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

COMPASS: a complex of proteins associated with a trithorax-related SET domain protein

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

Positional cloning of the gene for multiple endocrine neoplasia-type 1

19 March 2017

1 reference

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The HCF repeat is an unusual proteolytic cleavage signal

19 March 2017

1 reference

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The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

MLL targets SET domain methyltransferase activity to Hox gene promoters

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation

19 March 2017

1 reference

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The PHD finger: implications for chromatin-mediated transcriptional regulation

7 April 2017

1 reference

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Altered Hox expression and segmental identity in Mll-mutant mice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

BIG-3, a novel WD-40 repeat protein, is expressed in the developing growth plate and accelerates chondrocyte differentiation in vitro

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

The herpes simplex virus VP16-induced complex: the makings of a regulatory switch

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

Transcriptional activation is a key function encoded by MLL fusion partners

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

Menin interacting proteins as clues toward the understanding of multiple endocrine neoplasia type 1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

Unsafe SETs: histone lysine methyltransferases and cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

SET-domain proteins of the Su(var)3-9, E(z) and trithorax families

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

Mll rearrangements in haematological malignancies: lessons from clinical and biological studies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

The HRX proto-oncogene product is widely expressed in human tissues and localizes to nuclear structures

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

A single-point mutation in HCF causes temperature-sensitive cell-cycle arrest and disrupts VP16 function.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

Trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

Molecular cloning of a human protein that binds to the retinoblastoma protein and chromosomal mapping

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

Dimerization of MLL fusion proteins immortalizes hematopoietic cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

Functional studies of the MEN1 gene.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

Trans-regulation of thoracic homeotic selector genes of the Antennapedia and bithorax complexes by the trithorax group genes: absent, small, and homeotic discs 1 and 2.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

The bithorax complex is regulated by trithorax earlier during Drosophila embryogenesis than is the Antennapedia complex, correlating with a bithorax-like expression pattern of distinct early trithorax transcripts.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480881

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

29 November 2018

1 reference

12 December 2020

Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4 : 11) abnormality

1 reference

12 December 2020

An atlas of chromosomes in hematological malignancies. Example: 11q23 and MLL partners

1 reference

12 December 2020

Turning on a dimer: new insights into MLL chimeras

1 reference

12 December 2020

Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex

1 reference

12 December 2020

Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia

1 reference

12 December 2020

10.1128/MCB.24.13.5639-5649.2004

Identifiers

DOI

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2657983

2657983

1 reference

1 reference

1 reference