The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1 (Q24297392)

GOA release 2020-03-11

Mark A Rubin

7

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Dolores Di Vizio

4

object named as

Dolores Di Vizio

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Natalya N Pavlova

6

object named as

Natalya Pavlova

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author name string

Bekir Cinar

1

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Ping-Ke Fang

2

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Mohini Lutchman

3

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Rosalyn M Adam

5

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Pamela C Yelick

8

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Michael R Freeman

Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras

9

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language of work or name

English

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publication date

31 October 2007

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published in

The EMBO Journal

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volume

26

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issue

21

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page(s)

4523-34

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cites work

1 reference

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Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation

19 March 2017

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Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

19 March 2017

1 reference

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Mechanism of activation of protein kinase B by insulin and IGF-1

19 March 2017

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

19 March 2017

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

19 March 2017

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Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT

19 March 2017

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Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase

19 March 2017

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Regulation of Akt/PKB activation by tyrosine phosphorylation

19 March 2017

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Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage

19 March 2017

1 reference

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The phosphatidylinositol 3'-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells

19 March 2017

1 reference

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Role of translocation in the activation and function of protein kinase B

19 March 2017

1 reference

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

19 March 2017

1 reference

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Cholesterol sensitivity of endogenous and myristoylated Akt.

7 April 2017

1 reference

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Identification of a tumour suppressor network opposing nuclear Akt function

27 September 2017

1 reference

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Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis.

27 September 2017

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Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition

27 September 2017

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The Akt/PKB pathway: molecular target for cancer drug discovery

27 September 2017

1 reference

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Akt-regulated pathways in prostate cancer

27 September 2017

1 reference

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Regulation of the Akt kinase by interacting proteins

27 September 2017

1 reference

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Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts

27 September 2017

1 reference

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Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.

27 September 2017

1 reference

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Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

27 September 2017

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Mammalian Sterile20-like kinase 1 and the regulation of apoptosis

27 September 2017

1 reference

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Cholesterol and prostate cancer

27 September 2017

1 reference

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Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063482

Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy

27 September 2017

1 reference

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Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063482

Regulation of mammalian STE20-like kinase 2 (MST2) by protein phosphorylation/dephosphorylation and proteolysis

27 September 2017

1 reference

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Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063482

Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063482

Apoptosis stimulated by the 91-kDa caspase cleavage MEKK1 fragment requires translocation to soluble cellular compartments

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063482

Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

27 September 2017

1 reference

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Androgen receptor mediates the reduced tumor growth, enhanced androgen responsiveness, and selected target gene transactivation in a human prostate cancer cell line.

27 September 2017

1 reference

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Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway.

27 September 2017

1 reference

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Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063482

Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063482

Determination of the non-ionic detergent insolubility and phosphoprotein associations of glycosylphosphatidylinositol-anchored proteins expressed on T cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063482

Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063482

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063482

RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063482

AKT can be activated in the nucleus.

29 November 2018

1 reference

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Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063482

High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063482

Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063482

GM1-Containing Lipid Rafts Are Depleted within Clathrin-Coated Pits

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063482

HMG-CoA reductase inhibitors promote cholesterol-dependent Akt/PKB translocation to membrane domains in endothelial cells

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063482

Dissection of angiogenic signaling in zebrafish using a chemical genetic approach

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063482

Cholesterol-rich lipid rafts mediate akt-regulated survival in prostate cancer cells

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063482

Frequent inactivation of PTEN/MMAC1 in primary prostate cancer

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063482

Loss of PTEN is associated with progression to androgen independence

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17932490

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.EMBOJ.7601872

1 reference

691261

691261

1 reference

1 reference

1 reference