WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells (Q28508342)

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English	WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells	scientific journal article

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scholarly article

1 reference

24 January 2017

WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells (English)

1 reference

24 January 2017

endoplasmic reticulum

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apoptotic process

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Wolframin ER transmembrane glycoprotein

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GOA release 2020-03-11

author name string

Takahiro Yamada

1

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24 January 2017

Hisamitsu Ishihara

2

1 reference

24 January 2017

Akira Tamura

3

1 reference

24 January 2017

Rui Takahashi

4

1 reference

24 January 2017

Suguru Yamaguchi

5

1 reference

24 January 2017

Daisuke Takei

6

1 reference

24 January 2017

Ai Tokita

7

1 reference

24 January 2017

Chihiro Satake

8

1 reference

24 January 2017

Fumi Tashiro

9

1 reference

24 January 2017

Hideki Katagiri

10

1 reference

24 January 2017

Hiroyuki Aburatani

11

1 reference

24 January 2017

Jun-ichi Miyazaki

12

1 reference

24 January 2017

Yoshitomo Oka

13

1 reference

24 January 2017

language of work or name

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based on heuristic

inferred from title

publication date

15 May 2006

1 reference

24 January 2017

Human Molecular Genetics

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24 January 2017

15

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24 January 2017

1600–1609

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24 January 2017

10

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24 January 2017

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

Type 2 diabetes-a matter of beta-cell life and death?

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

Monogenic syndromes of abnormal glucose homeostasis: clinical review and relevance to the understanding of the pathology of insulin resistance and beta cell failure.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

Endoplasmic reticulum stress and the development of diabetes: a review

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https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

From acute ER stress to physiological roles of the Unfolded Protein Response

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

The mammalian unfolded protein response

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

Endoplasmic reticulum stress and N-glycosylation modulate expression of WFS1 protein

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic beta-cells via transcriptional activation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

PERK mediates cell-cycle exit during the mammalian unfolded protein response

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

GADD153-mediated anticancer effects of N-(4-hydroxyphenyl)retinamide on human hepatoma cells.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

Gadd34 functional domains involved in growth suppression and apoptosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

GADD34 induces p53 phosphorylation and p21/WAF1 transcription

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

CDK inhibitors: positive and negative regulators of G1-phase progression

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

Multiple signals induce endoplasmic reticulum stress in both primary and immortalized chondrocytes resulting in loss of differentiation, impaired cell growth, and apoptosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

When translation meets metabolism: multiple links to diabetes

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1 reference

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21 January 2018

Constructing adenoviral vectors by using the circular form of the adenoviral genome cloned in a cosmid and the Cre-loxP recombination system

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

Functional effects of expression of wolframin-antisense transcripts in BRIN-BD11 β-cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL081

21 January 2018

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