Seeking the causes and solutions to imatinib-resistance in chronic myeloid leukemia (Q37811878)

23 August 2017

Seeking the causes and solutions to imatinib-resistance in chronic myeloid leukemia (English)

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23 August 2017

chronic myeloid leukemia

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D Bixby

1

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PubMed ID

21102425

23 August 2017

M Talpaz

series ordinal

2

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23 August 2017

19 November 2010

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23 August 2017

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23 August 2017

25

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23 August 2017

1

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23 August 2017

7-22

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https://scigraph.springernature.com/pub.10.1038/leu.2010.238

23 August 2017

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Active transport of imatinib into and out of cells: implications for drug resistance

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Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia

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7 January 2021

Dasatinib cellular uptake and efflux in chronic myeloid leukemia cells: therapeutic implications

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In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor

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7 January 2021

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7 January 2021

Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients

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7 January 2021

Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: a subanalysis of the IRIS study

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7 January 2021

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BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571.

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Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells

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Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells

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The interaction of the Bcr-Abl tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains

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Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity

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The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells

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Critical role for Gab2 in transformation by BCR/ABL

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ERK2, but not ERK1, mediates acquired and "de novo" resistance to imatinib mesylate: implication for CML therapy

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Leukaemogenesis: more than mutant genes

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Bcr-Abl-independent imatinib-resistant K562 cells show aberrant protein acetylation and increased sensitivity to histone deacetylase inhibitors

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7 January 2021

Anti-leukemic activity of valproic acid and imatinib mesylate on human Ph+ ALL and CML cells in vitro

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Combined effects of novel tyrosine kinase inhibitor AMN107 and histone deacetylase inhibitor LBH589 against Bcr-Abl-expressing human leukemia cells

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Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate

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Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.

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7 January 2021

Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.

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7 January 2021

Dasatinib induces durable cytogenetic responses in patients with chronic myelogenous leukemia in chronic phase with resistance or intolerance to imatinib.

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7 January 2021

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7 January 2021

Philadelphia-positive patients who already harbor imatinib-resistant Bcr-Abl kinase domain mutations have a higher likelihood of developing additional mutations associated with resistance to second- or third-line tyrosine kinase inhibitors.

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7 January 2021

Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets

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7 January 2021

Long-term outcome of patients with chronic myeloid leukemia treated with second-generation tyrosine kinase inhibitors after imatinib failure is predicted by the in vitro sensitivity of BCR-ABL kinase domain mutations

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7 January 2021

In vivo kinetics of kinase domain mutations in CML patients treated with dasatinib after failing imatinib

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7 January 2021

Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency

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7 January 2021

Resistance to dasatinib in Philadelphia-positive leukemia patients and the presence or the selection of mutations at residues 315 and 317 in the BCR-ABL kinase domain

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7 January 2021

Second-line treatment with dasatinib in patients resistant to imatinib can select novel inhibitor-specific BCR-ABL mutants in Ph+ ALL

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7 January 2021

Drug treatment is superior to allografting as first-line therapy in chronic myeloid leukemia

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Allogeneic hematopoietic stem cell transplantation (allo SCT) for chronic myeloid leukemia in the imatinib era: evaluation of its impact within a subgroup of the randomized German CML Study IV.

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Role of allo-SCT for CML in 2010.

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7 January 2021

Failure to achieve a major cytogenetic response by 12 months defines inadequate response in patients receiving nilotinib or dasatinib as second or subsequent line therapy for chronic myeloid leukemia

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7 January 2021

In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells

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7 January 2021

Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells

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7 January 2021

New developments in tyrosine kinase inhibitor therapy for newly diagnosed chronic myeloid leukemia

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7 January 2021

Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy

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7 January 2021

AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance

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7 January 2021

NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia

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7 January 2021

Aurora kinase inhibitors

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7 January 2021

Influence of pharmacogenetic variability on the pharmacokinetics and toxicity of the aurora kinase inhibitor danusertib

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7 January 2021

Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I.

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7 January 2021

Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity

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7 January 2021

KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation.

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7 January 2021

Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia

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7 January 2021

Results of dasatinib therapy in patients with early chronic-phase chronic myeloid leukemia

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7 January 2021

Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and -intolerant chronic-phase chronic myeloid leukemia

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7 January 2021

Phase 3 study of dasatinib 140 mg once daily versus 70 mg twice daily in patients with chronic myeloid leukemia in accelerated phase resistant or intolerant to imatinib: 15-month median follow-up

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7 January 2021

Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis.

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7 January 2021

Dasatinib in imatinib-resistant or imatinib-intolerant chronic myeloid leukemia in blast phase after 2 years of follow-up in a phase 3 study: efficacy and tolerability of 140 milligrams once daily and 70 milligrams twice daily

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7 January 2021

Dasatinib (BMS-354825) is active in Philadelphia chromosome-positive chronic myelogenous leukemia after imatinib and nilotinib (AMN107) therapy failure

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7 January 2021

Nilotinib as front-line treatment for patients with chronic myeloid leukemia in early chronic phase

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7 January 2021

Nilotinib for the frontline treatment of Ph(+) chronic myeloid leukemia

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7 January 2021

Nilotinib is active in chronic and accelerated phase chronic myeloid leukemia following failure of imatinib and dasatinib therapy.

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7 January 2021

Identifiers

DOI

10.1038/LEU.2010.238

1 reference

23 August 2017

1 reference

PubMed ID

21102425