Raf-1 proto-oncogene, serine/threonine kinase (Q410434)

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mammalian protein found in Homo sapiens
  • v-raf-1 murine leukemia viral oncogene-like protein 1
  • cRaf
  • C-Raf proto-oncogene, serine/threonine kinase
  • v-raf-1 murine leukemia viral oncogene homolog 1
  • raf proto-oncogene serine/threonine protein kinase
  • proto-oncogene c-RAF
  • RAF1
  • Raf-1
  • Oncogene RAF1
  • RAF proto-oncogene serine/threonine-protein kinase
edit
Language Label Description Also known as
English
Raf-1 proto-oncogene, serine/threonine kinase
mammalian protein found in Homo sapiens
  • v-raf-1 murine leukemia viral oncogene-like protein 1
  • cRaf
  • C-Raf proto-oncogene, serine/threonine kinase
  • v-raf-1 murine leukemia viral oncogene homolog 1
  • raf proto-oncogene serine/threonine protein kinase
  • proto-oncogene c-RAF
  • RAF1
  • Raf-1
  • Oncogene RAF1
  • RAF proto-oncogene serine/threonine-protein kinase

Statements

molecular function
protein binding
determination method
IPI
84 references
retrieved
8 April 2019
stated in
FAM83B mediates EGFR- and RAS-driven oncogenic transformation
GOA
curator
UniProt
UniProt protein ID
P04049
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells
GOA
curator
UniProt
UniProt protein ID
P04049
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells
GOA
curator
UniProt
UniProt protein ID
P04049
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Binding of c-Raf1 kinase to a conserved acidic sequence within the carboxyl-terminal region of the HIV-1 Nef protein
GOA
curator
UniProt
UniProt protein ID
P04049
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway
GOA
curator
UniProt
UniProt protein ID
P04049
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
A Novel SHOC2 Variant in Rasopathy
GOA
curator
UniProt
UniProt protein ID
P04049
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice
GOA
curator
UniProt
UniProt protein ID
P04049
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Conserved oncogenic behavior of the FAM83 family regulates MAPK signaling in human cancer
GOA
curator
UniProt
UniProt protein ID
P04049
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Nuclear Raf-1 kinase regulates the CXCR5 promoter by associating with NFATc3 to drive retinoic acid-induced leukemic cell differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Identification of interaction between MEK2 and A-Raf-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Activation of Raf-1 by 14-3-3 proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
The prolyl isomerase Pin1 enhances HER-2 expression and cellular transformation via its interaction with mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Spatial regulation of Raf kinase signaling by RKTG
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Structure homology and interaction redundancy for discovering virus-host protein interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of growth and survival of activated T cells by cell-transducing inhibitors of Ras
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Raf-1 is a binding partner of DSCR1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
ERK and PDE4 cooperate to induce RAF isoform switching in melanoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Endothelial nitric oxide synthase regulates N-Ras activation on the Golgi complex of antigen-stimulated T cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Identification of small-molecule inducers of pancreatic beta-cell expansion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
RAF inhibitors that evade paradoxical MAPK pathway activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of RKIP binding to the N-region of the Raf-1 kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Protein binding and signaling properties of RIN1 suggest a unique effector function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
14-3-3 proteins associate with cdc25 phosphatases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of human myoblast differentiation by PEBP4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Ras membrane orientation and nanodomain localization generate isoform diversity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Ras/Rap effector specificity determined by charge reversal
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Rb-Raf-1 interaction disruptor RRD-251 induces apoptosis in metastatic melanoma cells and synergizes with dacarbazine
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Nucleocytoplasmic transport of Alp7/TACC organizes spatiotemporal microtubule formation in fission yeast
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Allosteric gating of Son of sevenless activity by the histone domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
The membrane localization of Ras2p and the association between Cdc25p and Ras2-GTP are regulated by protein kinase A (PKA) in the yeast Saccharomyces cerevisiae
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Transformation Efficiency of RasQ61 Mutants Linked to Structural Features of the Switch Regions in the Presence of Raf
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of the protein kinase Raf-1 with 14-3-3 proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a novel Rac1-interacting protein involved in membrane ruffling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Dynamic changes in C-Raf phosphorylation and 14-3-3 protein binding in response to growth factor stimulation: differential roles of 14-3-3 protein binding sites
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Raf-1 kinase associates with Hepatitis C virus NS5A and regulates viral replication
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
A novel switch region regulates H-ras membrane orientation and signal output
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
K-Ras4B phosphorylation at Ser181 is inhibited by calmodulin and modulates K-Ras activity and function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Functional conservation of 14-3-3 isoforms in inhibiting bad-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
retrieved
8 April 2019
stated in
JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE RAF1 201244 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D019908
subject named as
Proto-Oncogene Proteins c-raf
0 references
PDB structure ID
 
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                  Retrieved from "https://www.wikidata.org/w/index.php?title=Q410434&oldid=2117522300"