RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration (Q24301773)

GOA release 2020-03-11

manganese ion binding

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A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

GOA release 2020-03-11

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Hailiang Hu

1

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Joanne M Bliss

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2

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Ying Wang

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3

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John Colicelli

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4

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language of work or name

English

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publication date

10 May 2005

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published in

Current Biology

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volume

15

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issue

9

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page(s)

815-23

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cites work

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7 January 2021

Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold.

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How do Abl family kinases regulate cell shape and movement?

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The Abl family kinases: mechanisms of regulation and signaling

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Autoinhibition of c-Abl

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Structural basis for the autoinhibition of c-Abl tyrosine kinase

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Bcr-Abl variants: biological and clinical aspects

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Essential roles for the Abl and Arg tyrosine kinases in neurulation

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7 January 2021

The complexity of Raf-1 regulation

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Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway

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7 January 2021

Cycling, stressed-out and nervous: cellular functions of c-Abl

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Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1.

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Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation

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7 January 2021

Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1.

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https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

Spatial control of the actin cytoskeleton in Drosophila epithelial cells

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7 January 2021

A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1

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7 January 2021

An intramolecular SH3-domain interaction regulates c-Abl activity

1 reference

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7 January 2021

The leukaemic oncoproteins Bcr-Abl and Tel-Abl (ETV6/Abl) have altered substrate preferences and activate similar intracellular signalling pathways.

1 reference

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7 January 2021

Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor

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https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to Hepatocyte Growth Factor.

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7 January 2021

Crk family adaptors-signalling complex formation and biological roles

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7 January 2021

BCR/ABL inhibition by an escort/phosphatase fusion protein

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7 January 2021

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7 January 2021

Protein binding and signaling properties of RIN1 suggest a unique effector function

1 reference

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7 January 2021

Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program

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7 January 2021

Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines

1 reference

https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes

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https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity

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https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension

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https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled

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https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

c-Abl phosphorylates Dok1 to promote filopodia during cell spreading

1 reference

https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions

1 reference

https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

1 reference

https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

Postsynaptic signaling and plasticity mechanisms

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https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein

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https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

Two distinct phosphorylation pathways have additive effects on Abl family kinase activation

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https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

BCR/ABL induces multiple abnormalities of cytoskeletal function

1 reference

https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

Tyrosine phosphorylation of the CrkII adaptor protein modulates cell migration

1 reference

https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021

The RAS effector RIN1 modulates the formation of aversive memories

1 reference

https://api.crossref.org/works/10.1016%2FJ.CUB.2005.03.049

7 January 2021