PI3K-dependent phosphorylation of Fbw7 modulates substrate degradation and activity (Q24304880)

identical protein binding

GOA release 2020-03-11

1 reference

The SCF ubiquitin ligase: insights into a molecular machine

GOA release 2020-03-11

1 reference

Martin Eilers

2

Martin

Eilers

1 reference

9 December 2023

Christina Schülein

1

Christina

Schülein

1 reference

9 December 2023

Nikita Popov

series ordinal

3

author given names

Nikita

author last names

Popov

1 reference

9 December 2023

language of work or name

English

0 references

publication date

21 July 2011

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published in

FEBS Letters

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volume

585

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issue

14

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page(s)

2151-7

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cites work

1 reference

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FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

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Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination

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The ubiquitin-specific protease USP28 is required for MYC stability

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Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase

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Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms

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The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation

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Fbw7 and Usp28 regulate myc protein stability in response to DNA damage

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Regulation of the tumour suppressor Fbw7α by PKC-dependent phosphorylation and cancer-associated mutations.

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Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase

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Inactivation of hCDC4 can cause chromosomal instability

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Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).

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FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression

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Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

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SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

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Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma

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Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3.

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The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling

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Notch-dependent cell cycle arrest and apoptosis in mouse embryonic fibroblasts lacking Fbxw7.

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

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Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

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Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism

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mTORC1 promotes survival through translational control of Mcl-1.

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Distinct thresholds govern Myc's biological output in vivo

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Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

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