Regulation of the tumour suppressor Fbw7α by PKC-dependent phosphorylation and cancer-associated mutations. (Q42918132)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20815813%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

Regulation of the tumour suppressor Fbw7α by PKC-dependent phosphorylation and cancer-associated mutations (English)

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13 February 2020

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Peter Joseph Jacques Parker

series ordinal

2

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13 February 2020

author name string

Joanne Durgan

series ordinal

1

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13 February 2020

language of work or name

English

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publication date

1 November 2010

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13 February 2020

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13 February 2020

volume

432

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13 February 2020

issue

1

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13 February 2020

page(s)

77-87

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Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10

13 February 2020

cites work

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Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

21 January 2018

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sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins

21 January 2018

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FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

21 January 2018

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Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

21 January 2018

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Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

21 January 2018

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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

21 January 2018

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Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

21 January 2018

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The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling

21 January 2018

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The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

21 January 2018

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The Fbxw7/hCdc4 tumor suppressor in human cancer

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FBXW7/hCDC4 is a general tumor suppressor in human cancer.

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A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size

21 January 2018

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Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms

21 January 2018

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Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase

21 January 2018

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Protein kinase C and other diacylglycerol effectors in cancer

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Protein kinase C epsilon: an oncogene and emerging tumor biomarker

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Protein kinase C iota: human oncogene, prognostic marker and therapeutic target

21 January 2018

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Protein kinase C: poised to signal

21 January 2018

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The identification and characterization of novel PKCepsilon phosphorylation sites provide evidence for functional cross-talk within the PKC superfamily

21 January 2018

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Novel phosphorylation site markers of protein kinase C delta activation

21 January 2018

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Involvement of epidermal growth factor-like domain of NELL proteins in the novel protein-protein interaction with protein kinase C

21 January 2018

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Kinase peptide specificity: improved determination and relevance to protein phosphorylation

21 January 2018

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Imaging protein kinase Calpha activation in cells

21 January 2018

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The landscape of somatic copy-number alteration across human cancers

21 January 2018

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Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

21 January 2018

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Proteomic and bioinformatic analysis of epithelial tight junction reveals an unexpected cluster of synaptic molecules

21 January 2018

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The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C.

21 January 2018

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Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase

21 January 2018

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Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.

21 January 2018

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Fbw7/hCDC4 dimerization regulates its substrate interactions

21 January 2018

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Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism

21 January 2018

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Phosphorylation of nuclear localization signal inhibits the ligand-dependent nuclear import of aryl hydrocarbon receptor

21 January 2018

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Classical nuclear localization signals: definition, function, and interaction with importin alpha

21 January 2018

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The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4.

21 January 2018

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Altered subcellular localization of tumor-specific cyclin E isoforms affects cyclin-dependent kinase 2 complex formation and proteasomal regulation.

21 January 2018

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Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

21 January 2018

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21 January 2018

Identifiers

DOI

10.1042/BJ20100799

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20815813%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference