Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as the primary off-target of tyrosine kinase inhibitors (Q24306212)

GOA release 2020-03-11

mast cell proliferation

1 reference

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

GOA release 2020-03-11

C Tripodo

3

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author name string

P Pittoni

series ordinal

1

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S Piconese

series ordinal

2

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M P Colombo

series ordinal

4

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language of work or name

English

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publication date

17 February 2011

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published in

Oncogene

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volume

30

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issue

7

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page(s)

757-69

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cites work

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Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo

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Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma

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Generation of a prostate from a single adult stem cell

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Development, migration, and survival of mast cells

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Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow

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Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells

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Distinct sets of genetic alterations in melanoma

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Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

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FcRgamma activation regulates inflammation-associated squamous carcinogenesis.

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Our perception of the mast cell from Paul Ehrlich to now.

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A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family.

21 January 2018

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In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction

21 January 2018

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Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations.

21 January 2018

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The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

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Molecular pathobiology of gastrointestinal stromal sarcomas.

21 January 2018

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Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

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MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis

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Mast cells and tumour angiogenesis: new insight from experimental carcinogenesis

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Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type hypersensitivity in vivo

21 January 2018

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Differential KIT expression in histological subtypes of adenoid cystic carcinoma (ACC) of the salivary gland.

21 January 2018

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High frequency of concomitant mastocytosis in patients with acute myeloid leukemia exhibiting the transforming KIT mutation D816V.

21 January 2018

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Mast cells and cancer--no longer just basic science

21 January 2018

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Immunomodulatory mast cells: negative, as well as positive, regulators of immunity

21 January 2018

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The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

The tyrosine kinase network regulating mast cell activation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

Mast cells are an essential hematopoietic component for polyp development

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

Knock-in murine models of familial gastrointestinal stromal tumours

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

SCF-mediated mast cell infiltration and activation exacerbate the inflammation and immunosuppression in tumor microenvironment

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

Kit ligand and c-Kit have diverse roles during mammalian oogenesis and folliculogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

In vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

Differential expression of the c-kit proto-oncogene in germ cell tumours.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

Mast cells are novel independent prognostic markers in prostate cancer and represent a target for therapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

KIT mutations are common in testicular seminomas

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

The essential role of mast cells in orchestrating inflammation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

The meaning of the c-kit proto-oncogene product in malignant transformation in human mammary epithelium.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

Imatinib mesylate inhibits CD4+ CD25+ regulatory T cell activity and enhances active immunotherapy against BCR-ABL- tumors

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

Heterogeneity of kinase inhibitor resistance mechanisms in GIST

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

Mast cells are essential intermediaries in regulatory T-cell tolerance

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

Embryonic expression of a haematopoietic growth factor encoded by the SI locus and the ligand for c-kit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Natural killer cell IFN-gamma levels predict long-term survival with imatinib mesylate therapy in gastrointestinal stromal tumor-bearing patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Mast cell infiltration correlates with poor prognosis in Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

A mouse model of a human multiple GIST family with KIT-Asp820Tyr mutation generated by a knock-in strategy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

EXEL-0862, a novel tyrosine kinase inhibitor, induces apoptosis in vitro and ex vivo in human mast cells expressing the KIT D816V mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Nonmyeloablative transplantation with or without alemtuzumab: comparison between 2 prospective studies in patients with lymphoproliferative disorders

21 January 2018

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Targeted therapies: the rare cancer paradigm

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.494

Pleomorphic characteristics of a germ-line KIT mutation in a large kindred with gastrointestinal stromal tumors, hyperpigmentation, and dysphagia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Oncogenic Kit signaling and therapeutic intervention in a mouse model of gastrointestinal stromal tumor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

A knock-in mouse model of gastrointestinal stromal tumor harboring kit K641E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Myxoid epithelioid gastrointestinal stromal tumor (GIST) with mast cell infiltrations: a subtype of GIST with mutations of platelet-derived growth factor receptor alpha gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Mast cell-specific Cre/loxP-mediated recombination in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Coexpression of stem cell factor and its receptor c-Kit in human malignant glioma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Mast cells and the neurofibroma microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

A novel dendritic cell subset involved in tumor immunosurveillance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Expression of c-kit and Slug correlates with invasion and metastasis of salivary adenoid cystic carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Prognostic influence of tumor-infiltrating mast cells in patients with follicular lymphoma treated with rituximab and CHOP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Systemic mast cell disease associated with primary ovarian mixed malignant germ cell tumor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Mast cells and pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Mast cells: the Jekyll and Hyde of tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Mast cells and Th17 cells contribute to the lymphoma-associated pro-inflammatory microenvironment of angioimmunoblastic T-cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Frequent KIT and epidermal growth factor receptor overexpressions in undifferentiated-type breast carcinomas with 'stem-cell-like' features

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Mast cells as regulators of adaptive immunity to tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Targeting KIT in melanoma: a paradigm of molecular medicine and targeted therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Mast cells mobilize myeloid-derived suppressor cells and Treg cells in tumor microenvironment via IL-17 pathway in murine hepatocarcinoma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Expression of c-kit proto-oncogene product in breast tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Early myeloid cells expressing c-KIT isoforms differ in signal transduction, survival and chemotactic responses to Stem Cell Factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Cardiomyogenic potential of C-kit(+)-expressing cells derived from neonatal and adult mouse hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Neurofibromas in NF1: Schwann cell origin and role of tumor environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Polyps wrap mast cells and Treg within tumorigenic tentacles

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Exploring a regulatory role for mast cells: 'MCregs'?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

A murine monoclonal antibody specific for a cell-surface antigen expressed by a subgroup of human myeloid leukaemias

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Multiple gastrointestinal stromal tumors in neurofibromatosis type 1: report of a case

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

K-ras is critical for modulating multiple c-kit-mediated cellular functions in wild-type and Nf1+/- mast cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Putative human liver progenitor cells in explanted liver

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Gastrointestinal stromal tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

A new allele sash (Wsh) at the W-locus and a spontaneous recessive lethal in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Familial gastrointestinal stromal tumor with hyperpigmentation: association with a germline mutation of the c-kit gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Human marrow-derived mesenchymal stem cells (MSCs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Generation and characterization of alpha-chymase-Cre transgenic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Mast cell-derived angiopoietin-1 plays a critical role in the growth of plasma cell tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Breast cancer is associated with loss of the c-kit oncogene product

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Mast cells in Waldenstrom's macroglobulinemia support lymphoplasmacytic cell growth through CD154/CD40 signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494

Piebaldism: an autonomous autosomal dominant entity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.494