SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production (Q24307854)

F-box and WD-40 domain protein 7

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

protein ubiquitination

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Jinhe Li

1

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Adele M Pauley

2

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Rick L Myers

3

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Rongqing Shuang

4

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John R Brashler

5

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Riqiang Yan

6

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Allen E Buhl

7

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Cara Ruble

8

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Mark E Gurney

Journal of Neurochemistry

9

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language of work or name

English

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publication date

September 2002

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published in

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volume

82

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page(s)

1540-8

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issue

6

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cites work

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

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Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

21 January 2018

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins

21 January 2018

1 reference

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Selective protein degradation: a journey's end within the proteasome

21 January 2018

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Subcellular localization of presenilins during mouse preimplantation development

21 January 2018

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Aggresomes: a cellular response to misfolded proteins

21 January 2018

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Monogenic determinants of familial Alzheimer's disease: presenilin-1 mutations

21 January 2018

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Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 January 2018

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Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

21 January 2018

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

21 January 2018

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HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

21 January 2018

1 reference

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Identification and expression analysis of a potential familial Alzheimer disease gene on chromosome 1 related to AD3.

21 January 2018

1 reference

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Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

21 January 2018

1 reference

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

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The ancient regulatory-protein family of WD-repeat proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

Mechanisms underlying ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease

21 January 2018

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

Crystal structure of a G-protein beta gamma dimer at 2.1A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

Degradation of CFTR by the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

Themes and variations on ubiquitylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

A family of mammalian F-box proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

Increased plasma amyloid beta protein 1-42 levels in Down syndrome

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

7 January 2021

Membrane topology of the C. elegans SEL-12 presenilin

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

7 January 2021

Protein topology of presenilin 1

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

7 January 2021

Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

7 January 2021

Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells

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https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

7 January 2021

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

7 January 2021

One ring to rule a superfamily of E3 ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2002.01105.X

7 January 2021