MCL1 apoptosis regulator, BCL2 family member (Q21112678)

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mammalian protein found in Homo sapiens
  • mcl1/EAT
  • Bcl2-L-3
  • bcl-2-like protein 3
  • bcl-2-related protein EAT/mcl1
  • MCL1
  • myeloid cell leukemia sequence 1 (BCL2-related)
  • myeloid cell leukemia ES
  • myeloid cell leukemia 1
  • induced myeloid leukemia cell differentiation protein Mcl-1
  • MCL1, BCL2 family apoptosis regulator
  • BCL2 family apoptosis regulator
  • Myeloid Cell Leukemia Sequence 1 Protein
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Language Label Description Also known as
English
MCL1 apoptosis regulator, BCL2 family member
mammalian protein found in Homo sapiens
  • mcl1/EAT
  • Bcl2-L-3
  • bcl-2-like protein 3
  • bcl-2-related protein EAT/mcl1
  • MCL1
  • myeloid cell leukemia sequence 1 (BCL2-related)
  • myeloid cell leukemia ES
  • myeloid cell leukemia 1
  • induced myeloid leukemia cell differentiation protein Mcl-1
  • MCL1, BCL2 family apoptosis regulator
  • BCL2 family apoptosis regulator
  • Myeloid Cell Leukemia Sequence 1 Protein

Statements

molecular function
protein binding
determination method
IPI
26 references
retrieved
8 April 2019
stated in
The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis
GOA
curator
UniProt
UniProt protein ID
Q07820
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Placental autophagy regulation by the BOK-MCL1 rheostat
GOA
curator
UniProt
UniProt protein ID
Q07820
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Caveolin-1 regulates Mcl-1 stability and anoikis in lung carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Mcl-1(128-350) fragment induces apoptosis through direct interaction with Bax
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Human Bop is a novel BH3-only member of the Bcl-2 protein family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Subcellular localization of PUMA regulates its pro-apoptotic activity in Burkitt's lymphoma B cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
The hepatitis C virus core protein contains a BH3 domain that regulates apoptosis through specific interaction with human Mcl-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Noxa is necessary for hydrogen peroxide-induced caspase-dependent cell death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
retrieved
8 April 2019
stated in
ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
determination method
IPI
cell component
biological process

Identifiers

MeSH descriptor ID
D064549
subject named as
Myeloid Cell Leukemia Sequence 1 Protein
0 references
PDB structure ID
 
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